Smith JF - Search Results

1

The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.

Hall J, Ralph EC, Shanker S, Wang H, Byrnes LJ, Horst R, Wong J, Brault A, Dumlao D, Smith JF, Dakin LA, Schmitt DC, Trujillo J, Vincent F, Griffor M, Aulabaugh AE. Hall J, et al. Among authors: smith jf. Protein Sci. 2017 Dec;26(12):2367-2380. doi: 10.1002/pro.3304. Epub 2017 Oct 25. Protein Sci. 2017. PMID: 28940468 Free PMC article.

2

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K. Hall J, et al. PLoS One. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843. eCollection 2017. PLoS One. 2017. PMID: 28934246 Free PMC article.

3

Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences.

Gerstenberger BS, Banker ME, Clark JD, Dowty ME, Fensome A, Gifford R, Griffor MC, Hegen M, Hollingshead BD, Knafels JD, Lin TH, Smith JF, Vajdos FF. Gerstenberger BS, et al. Among authors: smith jf. Sci Rep. 2020 Jun 2;10(1):8974. doi: 10.1038/s41598-020-65762-y. Sci Rep. 2020. PMID: 32488071 Free PMC article.

4

New kinase regulation mechanism found in HipBA: a bacterial persistence switch.

Evdokimov A, Voznesensky I, Fennell K, Anderson M, Smith JF, Fisher DA. Evdokimov A, et al. Among authors: smith jf. Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):875-9. doi: 10.1107/S0907444909018800. Epub 2009 Jul 17. Acta Crystallogr D Biol Crystallogr. 2009. PMID: 19622872

5

Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase.

Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB. Fisher DA, et al. Among authors: smith jf. J Biol Chem. 1998 Jun 19;273(25):15559-64. doi: 10.1074/jbc.273.25.15559. J Biol Chem. 1998. PMID: 9624146 Free article.

6

Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase.

Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB. Fisher DA, et al. Among authors: smith jf. Biochem Biophys Res Commun. 1998 May 29;246(3):570-7. doi: 10.1006/bbrc.1998.8684. Biochem Biophys Res Commun. 1998. PMID: 9618252

7

Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors.

Montgomery JI, Smith JF, Tomaras AP, Zaniewski R, McPherson CJ, McAllister LA, Hartman-Neumann S, Arcari JT, Lescoe M, Gutierrez J, Yuan Y, Limberakis C, Miller AA. Montgomery JI, et al. Among authors: smith jf. J Antibiot (Tokyo). 2015 Jun;68(6):361-7. doi: 10.1038/ja.2014.163. Epub 2014 Dec 3. J Antibiot (Tokyo). 2015. PMID: 25464974

8

Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Mitton-Fry MJ, Brickner SJ, Hamel JC, Brennan L, Casavant JM, Chen M, Chen T, Ding X, Driscoll J, Hardink J, Hoang T, Hua E, Huband MD, Maloney M, Marfat A, McCurdy SP, McLeod D, Plotkin M, Reilly U, Robinson S, Schafer J, Shepard RM, Smith JF, Stone GG, Subramanyam C, Yoon K, Yuan W, Zaniewski RP, Zook C. Mitton-Fry MJ, et al. Among authors: smith jf. Bioorg Med Chem Lett. 2013 May 15;23(10):2955-61. doi: 10.1016/j.bmcl.2013.03.047. Epub 2013 Mar 21. Bioorg Med Chem Lett. 2013. PMID: 23566517

9

Adolescent social anxiety is associated with diminished discrimination of anticipated threat and safety in the bed nucleus of the stria terminalis.

Hur J, Tillman RM, Kim HC, Didier P, Anderson AS, Islam S, Stockbridge MD, De Los Reyes A, DeYoung KA, Smith JF, Shackman AJ. Hur J, et al. Among authors: smith jf. J Psychopathol Clin Sci. 2024 Nov 7. doi: 10.1037/abn0000940. Online ahead of print. J Psychopathol Clin Sci. 2024. PMID: 39509181

10

The Case for Pre-Treatment Sperm Banking as Standard of Care for All Post-Pubertal Males with Cancer.

Nahata L, Halpern JA, Bendle K, Frias O, Orwig K, Reinecke J, Smith JF, Woodard T, Levine J. Nahata L, et al. Among authors: smith jf. J Adolesc Young Adult Oncol. 2024 Sep 30. doi: 10.1089/jayao.2024.0100. Online ahead of print. J Adolesc Young Adult Oncol. 2024. PMID: 39347597 No abstract available.

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