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Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs.
Tartour K, Nguyen XN, Appourchaux R, Assil S, Barateau V, Bloyet LM, Burlaud Gaillard J, Confort MP, Escudero-Perez B, Gruffat H, Hong SS, Moroso M, Reynard O, Reynard S, Decembre E, Ftaich N, Rossi A, Wu N, Arnaud F, Baize S, Dreux M, Gerlier D, Paranhos-Baccala G, Volchkov V, Roingeard P, Cimarelli A. Tartour K, et al. Among authors: gruffat h. PLoS Pathog. 2017 Sep 28;13(9):e1006610. doi: 10.1371/journal.ppat.1006610. eCollection 2017 Sep. PLoS Pathog. 2017. PMID: 28957419 Free PMC article.
[Lyon, a critical place for performing Virology research].
Gerlier D, Gruffat H, Mahieux R. Gerlier D, et al. Among authors: gruffat h. Virologie (Montrouge). 2019 Mar 1;23(2):43-44. doi: 10.1684/vir.2019.0766. Virologie (Montrouge). 2019. PMID: 31145090 Free article. French. No abstract available.
The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation.
Wu N, Nguyen XN, Wang L, Appourchaux R, Zhang C, Panthu B, Gruffat H, Journo C, Alais S, Qin J, Zhang N, Tartour K, Catez F, Mahieux R, Ohlmann T, Liu M, Du B, Cimarelli A. Wu N, et al. Among authors: gruffat h. PLoS Pathog. 2019 Oct 10;15(10):e1008093. doi: 10.1371/journal.ppat.1008093. eCollection 2019 Oct. PLoS Pathog. 2019. PMID: 31600344 Free PMC article.
Epstein - Barr virus transforming protein LMP-1 alters B cells gene expression by promoting accumulation of the oncoprotein ΔNp73α.
Accardi R, Fathallah I, Gruffat H, Mariggiò G, Le Calvez-Kelm F, Voegele C, Bartosch B, Hernandez-Vargas H, McKay J, Sylla BS, Manet E, Tommasino M. Accardi R, et al. Among authors: gruffat h. PLoS Pathog. 2013 Mar;9(3):e1003186. doi: 10.1371/journal.ppat.1003186. Epub 2013 Mar 14. PLoS Pathog. 2013. PMID: 23516355 Free PMC article.
Epstein-Barr virus down-regulates tumor suppressor DOK1 expression.
Siouda M, Frecha C, Accardi R, Yue J, Cuenin C, Gruffat H, Manet E, Herceg Z, Sylla BS, Tommasino M. Siouda M, et al. Among authors: gruffat h. PLoS Pathog. 2014 May 8;10(5):e1004125. doi: 10.1371/journal.ppat.1004125. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24809689 Free PMC article.
Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines.
Hernandez-Vargas H, Gruffat H, Cros MP, Diederichs A, Sirand C, Vargas-Ayala RC, Jay A, Durand G, Le Calvez-Kelm F, Herceg Z, Manet E, Wild CP, Tommasino M, Accardi R. Hernandez-Vargas H, et al. Among authors: gruffat h. Sci Rep. 2017 Jul 19;7(1):5852. doi: 10.1038/s41598-017-05713-2. Sci Rep. 2017. PMID: 28724958 Free PMC article.
[EBV/KSHV co-infection: an effective partnership].
Gruffat H, Manet E. Gruffat H, et al. Med Sci (Paris). 2018 Jan;34(1):79-82. doi: 10.1051/medsci/20183401017. Epub 2018 Jan 31. Med Sci (Paris). 2018. PMID: 29384100 Free article. Review. French.
EBV latent membrane protein 1 is a negative regulator of TLR9.
Fathallah I, Parroche P, Gruffat H, Zannetti C, Johansson H, Yue J, Manet E, Tommasino M, Sylla BS, Hasan UA. Fathallah I, et al. Among authors: gruffat h. J Immunol. 2010 Dec 1;185(11):6439-47. doi: 10.4049/jimmunol.0903459. Epub 2010 Oct 27. J Immunol. 2010. PMID: 20980631
83 results