Nijman SMB - Search Results

1

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.

Gerken PA, Wolstenhulme JR, Tumber A, Hatch SB, Zhang Y, Müller S, Chandler SA, Mair B, Li F, Nijman SMB, Konietzny R, Szommer T, Yapp C, Fedorov O, Benesch JLP, Vedadi M, Kessler BM, Kawamura A, Brennan PE, Smith MD. Gerken PA, et al. Among authors: nijman smb. Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15555-15559. doi: 10.1002/anie.201706788. Epub 2017 Nov 7. Angew Chem Int Ed Engl. 2017. PMID: 28976073 Free PMC article.

2

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity.

Mair B, Konopka T, Kerzendorfer C, Sleiman K, Salic S, Serra V, Muellner MK, Theodorou V, Nijman SM. Mair B, et al. PLoS Genet. 2016 Sep 2;12(9):e1006279. doi: 10.1371/journal.pgen.1006279. eCollection 2016 Sep. PLoS Genet. 2016. PMID: 27588951 Free PMC article.

3

Exploiting epigenetic vulnerabilities for cancer therapeutics.

Mair B, Kubicek S, Nijman SM. Mair B, et al. Trends Pharmacol Sci. 2014 Mar;35(3):136-45. doi: 10.1016/j.tips.2014.01.001. Epub 2014 Feb 12. Trends Pharmacol Sci. 2014. PMID: 24529765 Review.

4

MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.

Smida M, Fece de la Cruz F, Kerzendorfer C, Uras IZ, Mair B, Mazouzi A, Suchankova T, Konopka T, Katz AM, Paz K, Nagy-Bojarszky K, Muellner MK, Bago-Horvath Z, Haura EB, Loizou JI, Nijman SM. Smida M, et al. Nat Commun. 2016 Dec 6;7:13701. doi: 10.1038/ncomms13701. Nat Commun. 2016. PMID: 27922010 Free PMC article.

5

Targeting a cell state common to triple-negative breast cancers.

Muellner MK, Mair B, Ibrahim Y, Kerzendorfer C, Lechtermann H, Trefzer C, Klepsch F, Müller AC, Leitner E, Macho-Maschler S, Superti-Furga G, Bennett KL, Baselga J, Rix U, Kubicek S, Colinge J, Serra V, Nijman SM. Muellner MK, et al. Mol Syst Biol. 2015 Feb 19;11(1):789. doi: 10.15252/msb.20145664. Mol Syst Biol. 2015. PMID: 25699542 Free PMC article.

6

Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells.

Forment JV, Herzog M, Coates J, Konopka T, Gapp BV, Nijman SM, Adams DJ, Keane TM, Jackson SP. Forment JV, et al. Nat Chem Biol. 2017 Jan;13(1):12-14. doi: 10.1038/nchembio.2226. Epub 2016 Oct 31. Nat Chem Biol. 2017. PMID: 27820796 Free PMC article.

7

TOPS: a versatile software tool for statistical analysis and visualization of combinatorial gene-gene and gene-drug interaction screens.

Muellner MK, Duernberger G, Ganglberger F, Kerzendorfer C, Uras IZ, Schoenegger A, Bagienski K, Colinge J, Nijman SM. Muellner MK, et al. BMC Bioinformatics. 2014 Apr 8;15:98. doi: 10.1186/1471-2105-15-98. BMC Bioinformatics. 2014. PMID: 24712852 Free PMC article.

8

A thesaurus of genetic variation for interrogation of repetitive genomic regions.

Kerzendorfer C, Konopka T, Nijman SM. Kerzendorfer C, et al. Nucleic Acids Res. 2015 May 26;43(10):e68. doi: 10.1093/nar/gkv178. Epub 2015 Mar 27. Nucleic Acids Res. 2015. PMID: 25820428 Free PMC article.

9

Comparison of genetic variants in matched samples using thesaurus annotation.

Konopka T, Nijman SM. Konopka T, et al. Bioinformatics. 2016 Mar 1;32(5):657-63. doi: 10.1093/bioinformatics/btv654. Epub 2015 Nov 5. Bioinformatics. 2016. PMID: 26545822 Free PMC article.

10

Light-assisted small-molecule screening against protein kinases.

Inglés-Prieto Á, Reichhart E, Muellner MK, Nowak M, Nijman SM, Grusch M, Janovjak H. Inglés-Prieto Á, et al. Nat Chem Biol. 2015 Dec;11(12):952-4. doi: 10.1038/nchembio.1933. Epub 2015 Oct 12. Nat Chem Biol. 2015. PMID: 26457372 Free PMC article.

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