Hawkins CJ - Search Results

1

Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine.

Miles MA, Hawkins CJ. Miles MA, et al. Among authors: hawkins cj. Cell Death Dis. 2017 Oct 5;8(10):e3062. doi: 10.1038/cddis.2017.454. Cell Death Dis. 2017. PMID: 28981092 Free PMC article.

2

Caspase-2: controversial killer or checkpoint controller?

Kitevska T, Spencer DM, Hawkins CJ. Kitevska T, et al. Among authors: hawkins cj. Apoptosis. 2009 Jul;14(7):829-48. doi: 10.1007/s10495-009-0365-3. Apoptosis. 2009. PMID: 19479377 Review.

3

TRAIL treatment provokes mutations in surviving cells.

Lovric MM, Hawkins CJ. Lovric MM, et al. Among authors: hawkins cj. Oncogene. 2010 Sep 9;29(36):5048-60. doi: 10.1038/onc.2010.242. Epub 2010 Jul 19. Oncogene. 2010. PMID: 20639907 Free PMC article.

4

Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells.

Shekhar TM, Green MM, Rayner DM, Miles MA, Cutts SM, Hawkins CJ. Shekhar TM, et al. Among authors: hawkins cj. Mutat Res. 2015 Jul;777:23-32. doi: 10.1016/j.mrfmmm.2015.04.005. Epub 2015 Apr 15. Mutat Res. 2015. PMID: 25916945

5

TRAIL causes deletions at the HPRT and TK1 loci of clonogenically competent cells.

Miles MA, Shekhar TM, Hall NE, Hawkins CJ. Miles MA, et al. Among authors: hawkins cj. Mutat Res. 2016 May;787:15-31. doi: 10.1016/j.mrfmmm.2016.02.006. Epub 2016 Feb 18. Mutat Res. 2016. PMID: 26943263

6

IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.

Shekhar TM, Miles MA, Gupte A, Taylor S, Tascone B, Walkley CR, Hawkins CJ. Shekhar TM, et al. Among authors: hawkins cj. Oncotarget. 2016 Jun 7;7(23):33866-86. doi: 10.18632/oncotarget.8980. Oncotarget. 2016. PMID: 27129149 Free PMC article.

7

Old and Novel Functions of Caspase-2.

Miles MA, Kitevska-Ilioski T, Hawkins CJ. Miles MA, et al. Among authors: hawkins cj. Int Rev Cell Mol Biol. 2017;332:155-212. doi: 10.1016/bs.ircmb.2016.12.002. Epub 2017 Jan 27. Int Rev Cell Mol Biol. 2017. PMID: 28526132 Review.

8

Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways.

Miles MA, Hawkins CJ. Miles MA, et al. Among authors: hawkins cj. Sci Rep. 2018 Sep 26;8(1):14421. doi: 10.1038/s41598-018-32517-9. Sci Rep. 2018. PMID: 30258062 Free PMC article.

9

CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants.

Bloomer DT, Kitevska-Ilioski T, Pantaki-Eimany D, Ji Y, Miles MA, Heras B, Hawkins CJ. Bloomer DT, et al. Among authors: hawkins cj. Biochem J. 2019 May 7;476(9):1335-1357. doi: 10.1042/BCJ20190202. Biochem J. 2019. PMID: 30992316

10

Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent.

Miles MA, Harris MA, Hawkins CJ. Miles MA, et al. Among authors: hawkins cj. Apoptosis. 2019 Jun;24(5-6):404-413. doi: 10.1007/s10495-019-01543-x. Apoptosis. 2019. PMID: 30997620

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