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Page 1
The binding mode of side chain- and C3-modified epothilones to tubulin.
Erdélyi M, Navarro-Vázquez A, Pfeiffer B, Kuzniewski CN, Felser A, Widmer T, Gertsch J, Pera B, Díaz JF, Altmann KH, Carlomagno T. Erdélyi M, et al. Among authors: pera b. ChemMedChem. 2010 Jun 7;5(6):911-20. doi: 10.1002/cmdc.201000050. ChemMedChem. 2010. PMID: 20432490
Mechanism of action of the cytotoxic macrolides amphidinolide X and J.
Trigili C, Pera B, Barbazanges M, Cossy J, Meyer C, Pineda O, Rodríguez-Escrich C, Urpí F, Vilarrasa J, Díaz JF, Barasoain I. Trigili C, et al. Among authors: pera b. Chembiochem. 2011 May 2;12(7):1027-30. doi: 10.1002/cbic.201100042. Epub 2011 Apr 15. Chembiochem. 2011. PMID: 21500335 No abstract available.
Modulation of microtubule interprotofilament interactions by modified taxanes.
Matesanz R, Rodríguez-Salarichs J, Pera B, Canales A, Andreu JM, Jiménez-Barbero J, Bras W, Nogales A, Fang WS, Díaz JF. Matesanz R, et al. Among authors: pera b. Biophys J. 2011 Dec 21;101(12):2970-80. doi: 10.1016/j.bpj.2011.11.005. Epub 2011 Dec 20. Biophys J. 2011. PMID: 22208196 Free PMC article.
Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.
Field JJ, Pera B, Calvo E, Canales A, Zurwerra D, Trigili C, Rodríguez-Salarichs J, Matesanz R, Kanakkanthara A, Wakefield SJ, Singh AJ, Jiménez-Barbero J, Northcote P, Miller JH, López JA, Hamel E, Barasoain I, Altmann KH, Díaz JF. Field JJ, et al. Among authors: pera b. Chem Biol. 2012 Jun 22;19(6):686-98. doi: 10.1016/j.chembiol.2012.05.008. Chem Biol. 2012. PMID: 22726683 Free PMC article.
A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.
Coderch C, Tang Y, Klett J, Zhang SE, Ma YT, Shaorong W, Matesanz R, Pera B, Canales A, Jiménez-Barbero J, Morreale A, Díaz JF, Fang WS, Gago F. Coderch C, et al. Among authors: pera b. Org Biomol Chem. 2013 May 14;11(18):3046-56. doi: 10.1039/c3ob40407b. Org Biomol Chem. 2013. PMID: 23532250 Free article.
New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.
Pera B, Barasoain I, Pantazopoulou A, Canales A, Matesanz R, Rodriguez-Salarichs J, García-Fernandez LF, Moneo V, Jiménez-Barbero J, Galmarini CM, Cuevas C, Peñalva MA, Díaz JF, Andreu JM. Pera B, et al. ACS Chem Biol. 2013 Sep 20;8(9):2084-94. doi: 10.1021/cb400461j. Epub 2013 Aug 1. ACS Chem Biol. 2013. PMID: 23859655
23 results