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635 results

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Page 1
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA. Houl JH, et al. Among authors: jones de. Nat Commun. 2019 Dec 11;10(1):5654. doi: 10.1038/s41467-019-13508-4. Nat Commun. 2019. PMID: 31827085 Free PMC article.
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.
Brosey CA, Houl JH, Katsonis P, Balapiti-Modarage LPF, Bommagani S, Arvai A, Moiani D, Bacolla A, Link T, Warden LS, Lichtarge O, Jones DE, Ahmed Z, Tainer JA. Brosey CA, et al. Among authors: jones de. Prog Biophys Mol Biol. 2021 Aug;163:171-186. doi: 10.1016/j.pbiomolbio.2021.02.002. Epub 2021 Feb 23. Prog Biophys Mol Biol. 2021. PMID: 33636189 Free PMC article.
An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2.
Moiani D, Link TM, Brosey CA, Katsonis P, Lichtarge O, Kim Y, Joachimiak A, Ma Z, Kim IK, Ahmed Z, Jones DE, Tsutakawa SE, Tainer JA. Moiani D, et al. Among authors: jones de. Methods Enzymol. 2021;661:407-431. doi: 10.1016/bs.mie.2021.09.003. Epub 2021 Sep 27. Methods Enzymol. 2021. PMID: 34776222 Free PMC article.
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
Nguyen MT, Moiani D, Ahmed Z, Arvai AS, Namjoshi S, Shin DS, Fedorov Y, Selvik EJ, Jones DE, Pink J, Yan Y, Laverty DJ, Nagel ZD, Tainer JA, Gerson SL. Nguyen MT, et al. Among authors: jones de. Prog Biophys Mol Biol. 2021 Aug;163:143-159. doi: 10.1016/j.pbiomolbio.2021.02.004. Epub 2021 Mar 3. Prog Biophys Mol Biol. 2021. PMID: 33675849 Free PMC article.
Applying HT-SAXS to chemical ligand screening.
Brosey CA, Shen R, Moiani D, Jones DE, Burnett K, Hura GL, Tainer JA. Brosey CA, et al. Among authors: jones de. Methods Enzymol. 2023;678:331-350. doi: 10.1016/bs.mie.2022.09.022. Epub 2022 Nov 26. Methods Enzymol. 2023. PMID: 36641213 Free PMC article.
GRB2 enforces homology-directed repair initiation by MRE11.
Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, Tsai CL, Shen Q, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z. Ye Z, et al. Among authors: jones de. Sci Adv. 2021 Aug 4;7(32):eabe9254. doi: 10.1126/sciadv.abe9254. Print 2021 Aug. Sci Adv. 2021. PMID: 34348893 Free PMC article.
635 results