Tomkinson AE - Search Results

1

Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor.

Howes TRL, Sallmyr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE. Howes TRL, et al. Among authors: tomkinson ae. DNA Repair (Amst). 2017 Dec;60:29-39. doi: 10.1016/j.dnarep.2017.10.002. Epub 2017 Oct 10. DNA Repair (Amst). 2017. PMID: 29078112 Free PMC article.

2

Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins.

Matsumoto Y, Kim K, Hurwitz J, Gary R, Levin DS, Tomkinson AE, Park MS. Matsumoto Y, et al. Among authors: tomkinson ae. J Biol Chem. 1999 Nov 19;274(47):33703-8. doi: 10.1074/jbc.274.47.33703. J Biol Chem. 1999. PMID: 10559261 Free article.

3

Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair.

Levin DS, McKenna AE, Motycka TA, Matsumoto Y, Tomkinson AE. Levin DS, et al. Among authors: tomkinson ae. Curr Biol. 2000 Jul 27-Aug 10;10(15):919-22. doi: 10.1016/s0960-9822(00)00619-9. Curr Biol. 2000. PMID: 10959839 Free article.

4

Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line.

Goetz JD, Motycka TA, Han M, Jasin M, Tomkinson AE. Goetz JD, et al. Among authors: tomkinson ae. DNA Repair (Amst). 2005 Jun 8;4(6):649-54. doi: 10.1016/j.dnarep.2005.02.004. Epub 2005 Apr 7. DNA Repair (Amst). 2005. PMID: 15907772

5

Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair.

Chen X, Zhong S, Zhu X, Dziegielewska B, Ellenberger T, Wilson GM, MacKerell AD Jr, Tomkinson AE. Chen X, et al. Among authors: tomkinson ae. Cancer Res. 2008 May 1;68(9):3169-77. doi: 10.1158/0008-5472.CAN-07-6636. Cancer Res. 2008. PMID: 18451142 Free PMC article.

6

Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks.

Sallmyr A, Tomkinson AE, Rassool FV. Sallmyr A, et al. Among authors: tomkinson ae. Blood. 2008 Aug 15;112(4):1413-23. doi: 10.1182/blood-2007-07-104257. Epub 2008 Jun 4. Blood. 2008. PMID: 18524993 Free PMC article.

7

Identification and validation of human DNA ligase inhibitors using computer-aided drug design.

Zhong S, Chen X, Zhu X, Dziegielewska B, Bachman KE, Ellenberger T, Ballin JD, Wilson GM, Tomkinson AE, MacKerell AD Jr. Zhong S, et al. Among authors: tomkinson ae. J Med Chem. 2008 Aug 14;51(15):4553-62. doi: 10.1021/jm8001668. Epub 2008 Jul 17. J Med Chem. 2008. PMID: 18630893 Free PMC article.

8

Phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repair.

Vijayakumar S, Dziegielewska B, Levin DS, Song W, Yin J, Yang A, Matsumoto Y, Bermudez VP, Hurwitz J, Tomkinson AE. Vijayakumar S, et al. Among authors: tomkinson ae. Mol Cell Biol. 2009 Apr;29(8):2042-52. doi: 10.1128/MCB.01732-08. Epub 2009 Feb 17. Mol Cell Biol. 2009. PMID: 19223468 Free PMC article.

9

The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1.

Song W, Pascal JM, Ellenberger T, Tomkinson AE. Song W, et al. Among authors: tomkinson ae. DNA Repair (Amst). 2009 Aug 6;8(8):912-9. doi: 10.1016/j.dnarep.2009.05.002. Epub 2009 Jun 11. DNA Repair (Amst). 2009. PMID: 19523882 Free PMC article.

10

Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair.

Chen X, Ballin JD, Della-Maria J, Tsai MS, White EJ, Tomkinson AE, Wilson GM. Chen X, et al. Among authors: tomkinson ae. DNA Repair (Amst). 2009 Aug 6;8(8):961-8. doi: 10.1016/j.dnarep.2009.06.002. Epub 2009 Jul 8. DNA Repair (Amst). 2009. PMID: 19589734 Free PMC article.

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