Derks M - Search Results

1

Results and evaluation of a first-in-human study of RG7342, an mGlu5 positive allosteric modulator, utilizing Bayesian adaptive methods.

Sturm S, Delporte ML, Hadi S, Schobel S, Lindemann L, Weikert R, Jaeschke G, Derks M, Palermo G. Sturm S, et al. Among authors: derks m. Br J Clin Pharmacol. 2018 Mar;84(3):445-455. doi: 10.1111/bcp.13466. Epub 2017 Dec 18. Br J Clin Pharmacol. 2018. PMID: 29096426 Free PMC article. Clinical Trial.

2

Lack of effect of dalcetrapib on QT interval in healthy subjects following multiple dosing.

Derks M, Abt M, Mwangi A, Meneses-Lorente G. Derks M, et al. Eur J Clin Pharmacol. 2010 Aug;66(8):775-83. doi: 10.1007/s00228-010-0841-2. Epub 2010 Jun 3. Eur J Clin Pharmacol. 2010. PMID: 20521033 Clinical Trial.

3

Lack of clinically relevant drug-drug interactions when dalcetrapib is co-administered with ezetimibe.

Derks M, Abt M, Phelan M. Derks M, et al. Br J Clin Pharmacol. 2010 Dec;70(6):825-33. doi: 10.1111/j.1365-2125.2010.03763.x. Br J Clin Pharmacol. 2010. PMID: 21175438 Free PMC article. Clinical Trial.

4

No clinically relevant drug-drug interactions when dalcetrapib is co-administered with a monophasic oral contraceptive (Microgynon® 30).

Young A, Anzures-Cabrera J, Derks M. Young A, et al. Among authors: derks m. Int J Clin Pharmacol Ther. 2012 Apr;50(4):248-56. doi: 10.5414/cp201647. Int J Clin Pharmacol Ther. 2012. PMID: 22456295 Clinical Trial.

5

Bayesian adaptive designs in single ascending dose trials in healthy volunteers.

Guédé D, Reigner B, Vandenhende F, Derks M, Beyer U, Jordan P, Worth E, Diack C, Frey N, Peck R. Guédé D, et al. Among authors: derks m. Br J Clin Pharmacol. 2014 Aug;78(2):393-400. doi: 10.1111/bcp.12344. Br J Clin Pharmacol. 2014. PMID: 24528176 Free PMC article.

6

Population Pharmacokinetic and Exposure-dizziness Modeling for a Metabotropic Glutamate Receptor Subtype 5 Negative Allosteric Modulator in Major Depressive Disorder Patients.

Cosson V, Schaedeli-Stark F, Arab-Alameddine M, Chavanne C, Guerini E, Derks M, Mallalieu NL. Cosson V, et al. Among authors: derks m. Clin Transl Sci. 2018 Sep;11(5):523-531. doi: 10.1111/cts.12566. Epub 2018 Jun 27. Clin Transl Sci. 2018. PMID: 29877614 Free PMC article. Clinical Trial.

7

Bioavailability and pharmacokinetic profile of balovaptan, a selective, brain-penetrant vasopressin 1a receptor antagonist, in healthy volunteers.

Derks M, Lennon-Chrimes S, Guenther A, Squassante L, Wandel C, Szczesny P, Paehler A, Kletzl H. Derks M, et al. Expert Opin Investig Drugs. 2021 Aug;30(8):893-901. doi: 10.1080/13543784.2021.1948009. Epub 2021 Jul 16. Expert Opin Investig Drugs. 2021. PMID: 34176392 Clinical Trial.

8

A single-center, open-label, one-sequence study of dalcetrapib coadministered with ketoconazole, and an in vitro study of the S-methyl metabolite of dalcetrapib.

Derks M, Fowler S, Kuhlmann O. Derks M, et al. Clin Ther. 2009 Mar;31(3):586-99. doi: 10.1016/j.clinthera.2009.02.011. Clin Ther. 2009. PMID: 19393849 Clinical Trial.

9

Coadministration of dalcetrapib with pravastatin, rosuvastatin, or simvastatin: no clinically relevant drug-drug interactions.

Derks M, Abt M, Phelan M, Turnbull L, Meneses-Lorente G, Bech N, White AM, Parr G. Derks M, et al. J Clin Pharmacol. 2010 Oct;50(10):1188-201. doi: 10.1177/0091270009358709. Epub 2010 May 20. J Clin Pharmacol. 2010. PMID: 20489031 Clinical Trial.

10

Safety, tolerability and pharmacokinetics of dalcetrapib following single and multiple ascending doses in healthy subjects: a randomized, double-blind, placebo-controlled, phase I study.

Derks M, Anzures-Cabrera J, Turnbull L, Phelan M. Derks M, et al. Clin Drug Investig. 2011;31(5):325-35. doi: 10.1007/BF03256931. Clin Drug Investig. 2011. PMID: 21366361 Clinical Trial.

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