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Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.
Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng X, Carrier EJ, Mann MK, Giovannoni G, Pertwee RG, Yamamura T, Buckley NE, Hillard CJ, Lutz B, Baker D, Dittel BN. Maresz K, et al. Among authors: hillard cj. Nat Med. 2007 Apr;13(4):492-7. doi: 10.1038/nm1561. Epub 2007 Apr 1. Nat Med. 2007. PMID: 17401376
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling.
Pan B, Wang W, Long JZ, Sun D, Hillard CJ, Cravatt BF, Liu QS. Pan B, et al. Among authors: hillard cj. J Pharmacol Exp Ther. 2009 Nov;331(2):591-7. doi: 10.1124/jpet.109.158162. Epub 2009 Aug 7. J Pharmacol Exp Ther. 2009. PMID: 19666749 Free PMC article.
272 results