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ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas.
Wang W, Friedland SC, Guo B, O'Dell MR, Alexander WB, Whitney-Miller CL, Agostini-Vulaj D, Huber AR, Myers JR, Ashton JM, Dunne RF, Steiner LA, Hezel AF. Wang W, et al. Among authors: hezel af. Gut. 2019 Jul;68(7):1245-1258. doi: 10.1136/gutjnl-2017-315541. Epub 2018 Sep 18. Gut. 2019. PMID: 30228219 Free PMC article.
Smad4 restricts injury-provoked biliary proliferation and carcinogenesis.
Alexander WB, Wang W, Hill MA, O'Dell MR, Ruffolo LI, Guo B, Jackson KM, Ullman N, Friedland SC, McCall MN, Patel A, Figueroa-Guilliani N, Georger M, Belt BA, Whitney-Miller CL, Linehan DC, Murphy PJ, Hezel AF. Alexander WB, et al. Among authors: hezel af. Dis Model Mech. 2024 Jun 1;17(6):dmm050358. doi: 10.1242/dmm.050358. Epub 2024 Feb 28. Dis Model Mech. 2024. PMID: 38415925 Free PMC article.
Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma.
Guo B, Friedland SC, Alexander W, Myers JA, Wang W, O'Dell MR, Getman M, Whitney-Miller CL, Agostini-Vulaj D, Huber AR, Mello SS, Vertino PM, Land HK, Steiner LA, Hezel AF. Guo B, et al. Among authors: hezel af. Cell Rep. 2022 Aug 30;40(9):111253. doi: 10.1016/j.celrep.2022.111253. Cell Rep. 2022. PMID: 36044839 Free PMC article.
Telomere induced senescence: end game signaling.
Hezel AF, Bardeesy N, Maser RS. Hezel AF, et al. Curr Mol Med. 2005 Mar;5(2):145-52. doi: 10.2174/1566524053586563. Curr Mol Med. 2005. PMID: 15974867 Review.
77 results