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Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy.
Jelcic I, Combaluzier B, Jelcic I, Faigle W, Senn L, Reinhart BJ, Ströh L, Nitsch RM, Stehle T, Sospedra M, Grimm J, Martin R. Jelcic I, et al. Among authors: grimm j. Sci Transl Med. 2015 Sep 23;7(306):306ra150. doi: 10.1126/scitranslmed.aac8691. Epub 2015 Sep 23. Sci Transl Med. 2015. PMID: 26400911 Free PMC article.
Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses.
Geoghegan EM, Pastrana DV, Schowalter RM, Ray U, Gao W, Ho M, Pauly GT, Sigano DM, Kaynor C, Cahir-McFarland E, Combaluzier B, Grimm J, Buck CB. Geoghegan EM, et al. Among authors: grimm j. Cell Rep. 2017 Oct 31;21(5):1169-1179. doi: 10.1016/j.celrep.2017.10.027. Cell Rep. 2017. PMID: 29091757 Free PMC article.
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Weihofen A, Liu Y, Arndt JW, Huy C, Quan C, Smith BA, Baeriswyl JL, Cavegn N, Senn L, Su L, Marsh G, Auluck PK, Montrasio F, Nitsch RM, Hirst WD, Cedarbaum JM, Pepinsky RB, Grimm J, Weinreb PH. Weihofen A, et al. Among authors: grimm j. Neurobiol Dis. 2019 Apr;124:276-288. doi: 10.1016/j.nbd.2018.10.016. Epub 2018 Oct 28. Neurobiol Dis. 2019. PMID: 30381260 Free article.
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.
Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, Dunah AW, Wittmann M, Bussiere T, Weinreb PH, Hyman BT, Takeda S. Nobuhara CK, et al. Among authors: grimm j. Am J Pathol. 2017 Jun;187(6):1399-1412. doi: 10.1016/j.ajpath.2017.01.022. Epub 2017 Apr 11. Am J Pathol. 2017. PMID: 28408124 Free PMC article.
The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.
Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A. Sevigny J, et al. Among authors: grimm j. Nature. 2016 Sep 1;537(7618):50-6. doi: 10.1038/nature19323. Nature. 2016. Update in: Nature. 2017 Jun 21;546(7659):564. doi: 10.1038/nature22809 PMID: 27582220 Updated.
Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.
Nguyen L, Montrasio F, Pattamatta A, Tusi SK, Bardhi O, Meyer KD, Hayes L, Nakamura K, Banez-Coronel M, Coyne A, Guo S, Laboissonniere LA, Gu Y, Narayanan S, Smith B, Nitsch RM, Kankel MW, Rushe M, Rothstein J, Zu T, Grimm J, Ranum LPW. Nguyen L, et al. Among authors: grimm j. Neuron. 2020 Feb 19;105(4):645-662.e11. doi: 10.1016/j.neuron.2019.11.007. Epub 2019 Dec 9. Neuron. 2020. PMID: 31831332 Free PMC article.
Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice.
Santuccione AC, Merlini M, Shetty A, Tackenberg C, Bali J, Ferretti MT, McAfoose J, Kulic L, Bernreuther C, Welt T, Grimm J, Glatzel M, Rajendran L, Hock C, Nitsch RM. Santuccione AC, et al. Among authors: grimm j. Mol Psychiatry. 2013 Mar;18(3):358-68. doi: 10.1038/mp.2012.70. Epub 2012 Jun 12. Mol Psychiatry. 2013. PMID: 22688190
901 results