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Page 1
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Brouwer JM, Lan P, Cowan AD, Bernardini JP, Birkinshaw RW, van Delft MF, Sleebs BE, Robin AY, Wardak A, Tan IK, Reljic B, Lee EF, Fairlie WD, Call MJ, Smith BJ, Dewson G, Lessene G, Colman PM, Czabotar PE. Brouwer JM, et al. Among authors: bernardini jp. Mol Cell. 2017 Nov 16;68(4):659-672.e9. doi: 10.1016/j.molcel.2017.11.001. Mol Cell. 2017. PMID: 29149594 Free article.
BAK core dimers bind lipids and can be bridged by them.
Cowan AD, Smith NA, Sandow JJ, Kapp EA, Rustam YH, Murphy JM, Brouwer JM, Bernardini JP, Roy MJ, Wardak AZ, Tan IK, Webb AI, Gulbis JM, Smith BJ, Reid GE, Dewson G, Colman PM, Czabotar PE. Cowan AD, et al. Among authors: bernardini jp. Nat Struct Mol Biol. 2020 Nov;27(11):1024-1031. doi: 10.1038/s41594-020-0494-5. Epub 2020 Sep 14. Nat Struct Mol Biol. 2020. PMID: 32929280
Dynamic reconfiguration of pro-apoptotic BAK on membranes.
Sandow JJ, Tan IK, Huang AS, Masaldan S, Bernardini JP, Wardak AZ, Birkinshaw RW, Ninnis RL, Liu Z, Dalseno D, Lio D, Infusini G, Czabotar PE, Webb AI, Dewson G. Sandow JJ, et al. Among authors: bernardini jp. EMBO J. 2021 Oct 18;40(20):e107237. doi: 10.15252/embj.2020107237. Epub 2021 Sep 15. EMBO J. 2021. PMID: 34523147 Free PMC article.
Parkin and mitophagy in cancer.
Bernardini JP, Lazarou M, Dewson G. Bernardini JP, et al. Oncogene. 2017 Mar;36(10):1315-1327. doi: 10.1038/onc.2016.302. Epub 2016 Sep 5. Oncogene. 2017. PMID: 27593930 Review.
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
Klemm T, Ebert G, Calleja DJ, Allison CC, Richardson LW, Bernardini JP, Lu BG, Kuchel NW, Grohmann C, Shibata Y, Gan ZY, Cooney JP, Doerflinger M, Au AE, Blackmore TR, van der Heden van Noort GJ, Geurink PP, Ovaa H, Newman J, Riboldi-Tunnicliffe A, Czabotar PE, Mitchell JP, Feltham R, Lechtenberg BC, Lowes KN, Dewson G, Pellegrini M, Lessene G, Komander D. Klemm T, et al. Among authors: bernardini jp. EMBO J. 2020 Sep 15;39(18):e106275. doi: 10.15252/embj.2020106275. Epub 2020 Aug 26. EMBO J. 2020. PMID: 32845033 Free PMC article.
Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development.
Aubrey BJ, Janic A, Chen Y, Chang C, Lieschke EC, Diepstraten ST, Kueh AJ, Bernardini JP, Dewson G, O'Reilly LA, Whitehead L, Voss AK, Smyth GK, Strasser A, Kelly GL. Aubrey BJ, et al. Among authors: bernardini jp. Genes Dev. 2018 Nov 1;32(21-22):1420-1429. doi: 10.1101/gad.314286.118. Epub 2018 Oct 26. Genes Dev. 2018. PMID: 30366906 Free PMC article.
Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.
Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, Kile BT, Josefsson EC. Pleines I, et al. Blood. 2018 Jul 12;132(2):197-209. doi: 10.1182/blood-2017-11-816355. Epub 2018 May 21. Blood. 2018. PMID: 29784641 Free article.
14 results