Donthamsetti PC - Search Results

1

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.

Donthamsetti PC, Winter N, Schönberger M, Levitz J, Stanley C, Javitch JA, Isacoff EY, Trauner D. Donthamsetti PC, et al. J Am Chem Soc. 2017 Dec 27;139(51):18522-18535. doi: 10.1021/jacs.7b07659. Epub 2017 Dec 13. J Am Chem Soc. 2017. PMID: 29166564 Free PMC article.

2

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Newman AH, Beuming T, Banala AK, Donthamsetti P, Pongetti K, LaBounty A, Levy B, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L. Newman AH, et al. J Med Chem. 2012 Aug 9;55(15):6689-99. doi: 10.1021/jm300482h. Epub 2012 Jun 7. J Med Chem. 2012. PMID: 22632094 Free PMC article.

3

A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.

Michino M, Donthamsetti P, Beuming T, Banala A, Duan L, Roux T, Han Y, Trinquet E, Newman AH, Javitch JA, Shi L. Michino M, et al. Mol Pharmacol. 2013 Dec;84(6):854-64. doi: 10.1124/mol.113.087833. Epub 2013 Sep 23. Mol Pharmacol. 2013. PMID: 24061855 Free PMC article.

4

A new mechanism of allostery in a G protein-coupled receptor dimer.

Lane JR, Donthamsetti P, Shonberg J, Draper-Joyce CJ, Dentry S, Michino M, Shi L, López L, Scammells PJ, Capuano B, Sexton PM, Javitch JA, Christopoulos A. Lane JR, et al. Nat Chem Biol. 2014 Sep;10(9):745-52. doi: 10.1038/nchembio.1593. Epub 2014 Aug 10. Nat Chem Biol. 2014. PMID: 25108820 Free PMC article.

5

Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor.

Clayton CC, Donthamsetti P, Lambert NA, Javitch JA, Neve KA. Clayton CC, et al. J Biol Chem. 2014 Nov 28;289(48):33663-75. doi: 10.1074/jbc.M114.605378. Epub 2014 Oct 21. J Biol Chem. 2014. PMID: 25336643 Free PMC article.

6

What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

Michino M, Beuming T, Donthamsetti P, Newman AH, Javitch JA, Shi L. Michino M, et al. Pharmacol Rev. 2015;67(1):198-213. doi: 10.1124/pr.114.009944. Pharmacol Rev. 2015. PMID: 25527701 Free PMC article. Review.

7

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.

Boateng CA, Bakare OM, Zhan J, Banala AK, Burzynski C, Pommier E, Keck TM, Donthamsetti P, Javitch JA, Rais R, Slusher BS, Xi ZX, Newman AH. Boateng CA, et al. J Med Chem. 2015 Aug 13;58(15):6195-213. doi: 10.1021/acs.jmedchem.5b00776. Epub 2015 Jul 23. J Med Chem. 2015. PMID: 26203768 Free PMC article.

8

Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors.

Donthamsetti P, Quejada JR, Javitch JA, Gurevich VV, Lambert NA. Donthamsetti P, et al. Curr Protoc Pharmacol. 2015 Sep 1;70:2.14.1-2.14.14. doi: 10.1002/0471141755.ph0214s70. Curr Protoc Pharmacol. 2015. PMID: 26331887 Free PMC article.

9

Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence.

Farino ZJ, Morgenstern TJ, Vallaghe J, Gregor N, Donthamsetti P, Harris PE, Pierre N, Freyberg R, Charrier-Savournin F, Javitch JA, Freyberg Z. Farino ZJ, et al. PLoS One. 2016 Feb 5;11(2):e0148684. doi: 10.1371/journal.pone.0148684. eCollection 2016. PLoS One. 2016. PMID: 26849707 Free PMC article.

10

The role of kinetic context in apparent biased agonism at GPCRs.

Klein Herenbrink C, Sykes DA, Donthamsetti P, Canals M, Coudrat T, Shonberg J, Scammells PJ, Capuano B, Sexton PM, Charlton SJ, Javitch JA, Christopoulos A, Lane JR. Klein Herenbrink C, et al. Nat Commun. 2016 Feb 24;7:10842. doi: 10.1038/ncomms10842. Nat Commun. 2016. PMID: 26905976 Free PMC article.

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