Javitch JA - Search Results

1

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.

Donthamsetti PC, Winter N, Schönberger M, Levitz J, Stanley C, Javitch JA, Isacoff EY, Trauner D. Donthamsetti PC, et al. Among authors: javitch ja. J Am Chem Soc. 2017 Dec 27;139(51):18522-18535. doi: 10.1021/jacs.7b07659. Epub 2017 Dec 13. J Am Chem Soc. 2017. PMID: 29166564 Free PMC article.

2

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.

Han Y, Moreira IS, Urizar E, Weinstein H, Javitch JA. Han Y, et al. Among authors: javitch ja. Nat Chem Biol. 2009 Sep;5(9):688-95. doi: 10.1038/nchembio.199. Epub 2009 Aug 2. Nat Chem Biol. 2009. PMID: 19648932 Free PMC article.

3

Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [11C] NNC112 and [11C] raclopride.

Slifstein M, Suckow RF, Javitch JA, Cooper T, Lieberman J, Abi-Dargham A. Slifstein M, et al. Among authors: javitch ja. J Cereb Blood Flow Metab. 2011 Jan;31(1):293-304. doi: 10.1038/jcbfm.2010.91. Epub 2010 Jun 23. J Cereb Blood Flow Metab. 2011. PMID: 20571519 Free PMC article.

4

CODA-RET reveals functional selectivity as a result of GPCR heteromerization.

Urizar E, Yano H, Kolster R, Galés C, Lambert N, Javitch JA. Urizar E, et al. Among authors: javitch ja. Nat Chem Biol. 2011 Jul 24;7(9):624-30. doi: 10.1038/nchembio.623. Nat Chem Biol. 2011. PMID: 21785426 Free PMC article.

5

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Newman AH, Beuming T, Banala AK, Donthamsetti P, Pongetti K, LaBounty A, Levy B, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L. Newman AH, et al. Among authors: javitch ja. J Med Chem. 2012 Aug 9;55(15):6689-99. doi: 10.1021/jm300482h. Epub 2012 Jun 7. J Med Chem. 2012. PMID: 22632094 Free PMC article.

6

A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.

Michino M, Donthamsetti P, Beuming T, Banala A, Duan L, Roux T, Han Y, Trinquet E, Newman AH, Javitch JA, Shi L. Michino M, et al. Among authors: javitch ja. Mol Pharmacol. 2013 Dec;84(6):854-64. doi: 10.1124/mol.113.087833. Epub 2013 Sep 23. Mol Pharmacol. 2013. PMID: 24061855 Free PMC article.

7

A new mechanism of allostery in a G protein-coupled receptor dimer.

Lane JR, Donthamsetti P, Shonberg J, Draper-Joyce CJ, Dentry S, Michino M, Shi L, López L, Scammells PJ, Capuano B, Sexton PM, Javitch JA, Christopoulos A. Lane JR, et al. Among authors: javitch ja. Nat Chem Biol. 2014 Sep;10(9):745-52. doi: 10.1038/nchembio.1593. Epub 2014 Aug 10. Nat Chem Biol. 2014. PMID: 25108820 Free PMC article.

8

Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor.

Clayton CC, Donthamsetti P, Lambert NA, Javitch JA, Neve KA. Clayton CC, et al. Among authors: javitch ja. J Biol Chem. 2014 Nov 28;289(48):33663-75. doi: 10.1074/jbc.M114.605378. Epub 2014 Oct 21. J Biol Chem. 2014. PMID: 25336643 Free PMC article.

9

What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

Michino M, Beuming T, Donthamsetti P, Newman AH, Javitch JA, Shi L. Michino M, et al. Among authors: javitch ja. Pharmacol Rev. 2015;67(1):198-213. doi: 10.1124/pr.114.009944. Pharmacol Rev. 2015. PMID: 25527701 Free PMC article. Review.

10

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.

Boateng CA, Bakare OM, Zhan J, Banala AK, Burzynski C, Pommier E, Keck TM, Donthamsetti P, Javitch JA, Rais R, Slusher BS, Xi ZX, Newman AH. Boateng CA, et al. Among authors: javitch ja. J Med Chem. 2015 Aug 13;58(15):6195-213. doi: 10.1021/acs.jmedchem.5b00776. Epub 2015 Jul 23. J Med Chem. 2015. PMID: 26203768 Free PMC article.

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