Ke A - Search Results

1

In vitro to in vivo extrapolation for high throughput prioritization and decision making.

Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes NS, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC. Bell SM, et al. Among authors: ke a. Toxicol In Vitro. 2018 Mar;47:213-227. doi: 10.1016/j.tiv.2017.11.016. Epub 2017 Dec 5. Toxicol In Vitro. 2018. PMID: 29203341 Free PMC article. Review.

2

Towards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6.

Ke A, Barter Z, Rowland-Yeo K, Almond L. Ke A, et al. CPT Pharmacometrics Syst Pharmacol. 2016 Jul;5(7):367-76. doi: 10.1002/psp4.12088. Epub 2016 Jul 20. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27435752 Free PMC article.

3

Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity.

Xie F, Ke AB, Bowers GD, Zamek-Gliszczynski MJ. Xie F, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):225-9. doi: 10.1124/jpet.115.225698. Epub 2015 Jun 10. J Pharmacol Exp Ther. 2015. PMID: 26062557

4

Physiologically Based Pharmacokinetic Modeling and Allometric Scaling in Pediatric Drug Development: Where Do We Draw the Line?

Johnson TN, Ke AB. Johnson TN, et al. J Clin Pharmacol. 2021 Jun;61 Suppl 1:S83-S93. doi: 10.1002/jcph.1834. J Clin Pharmacol. 2021. PMID: 34185901 Review.

5

Pharmacometrics in pregnancy: An unmet need.

Ke AB, Rostami-Hodjegan A, Zhao P, Unadkat JD. Ke AB, et al. Annu Rev Pharmacol Toxicol. 2014;54:53-69. doi: 10.1146/annurev-pharmtox-011613-140009. Annu Rev Pharmacol Toxicol. 2014. PMID: 24392692 Review.

6

Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.

Kilford PJ, Chen KF, Crewe K, Gardner I, Hatley O, Ke AB, Neuhoff S, Zhang M, Rowland Yeo K. Kilford PJ, et al. CPT Pharmacometrics Syst Pharmacol. 2022 Jul;11(7):822-832. doi: 10.1002/psp4.12794. Epub 2022 Apr 28. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35445542 Free PMC article.

7

Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug-Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Analysis.

Gupta N, Hanley MJ, Venkatakrishnan K, Bessudo A, Rasco DW, Sharma S, O'Neil BH, Wang B, Liu G, Ke A, Patel C, Rowland Yeo K, Xia C, Zhang X, Esseltine DL, Nemunaitis J. Gupta N, et al. Among authors: ke a. J Clin Pharmacol. 2018 Feb;58(2):180-192. doi: 10.1002/jcph.988. Epub 2017 Aug 11. J Clin Pharmacol. 2018. PMID: 28800141 Free PMC article. Clinical Trial.

8

PBPK modeling to predict drug-drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction.

Bolleddula J, Ke A, Yang H, Prakash C. Bolleddula J, et al. Among authors: ke a. CPT Pharmacometrics Syst Pharmacol. 2021 Jun;10(6):577-588. doi: 10.1002/psp4.12619. Epub 2021 May 1. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33822485 Free PMC article.

9

Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone-Atomoxetine Interaction.

Oggianu L, Ke AB, Chetty M, Picollo R, Petrucci V, Calisti F, Garofolo F, Tongiani S. Oggianu L, et al. CPT Pharmacometrics Syst Pharmacol. 2020 Feb;9(2):77-86. doi: 10.1002/psp4.12480. Epub 2020 Jan 11. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 31808613 Free PMC article.

10

Physiologically based pharmacokinetic modeling and simulation to predict drug-drug interactions of ivosidenib with CYP3A perpetrators in patients with acute myeloid leukemia.

Prakash C, Fan B, Ke A, Le K, Yang H. Prakash C, et al. Among authors: ke a. Cancer Chemother Pharmacol. 2020 Nov;86(5):619-632. doi: 10.1007/s00280-020-04148-3. Epub 2020 Sep 25. Cancer Chemother Pharmacol. 2020. PMID: 32978634

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