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The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity.
Cardarelli RA, Jones K, Pisella LI, Wobst HJ, McWilliams LJ, Sharpe PM, Burnham MP, Baker DJ, Chudotvorova I, Guyot J, Silayeva L, Morrow DH, Dekker N, Zicha S, Davies PA, Holenz J, Duggan ME, Dunlop J, Mather RJ, Wang Q, Medina I, Brandon NJ, Deeb TZ, Moss SJ. Cardarelli RA, et al. Among authors: baker dj. Nat Med. 2017 Dec 7;23(12):1394-1396. doi: 10.1038/nm.4442. Nat Med. 2017. PMID: 29216042 Free PMC article. No abstract available.
Molecular architecture of potassium chloride co-transporter KCC2.
Agez M, Schultz P, Medina I, Baker DJ, Burnham MP, Cardarelli RA, Conway LC, Garnier K, Geschwindner S, Gunnarsson A, McCall EJ, Frechard A, Audebert S, Deeb TZ, Moss SJ, Brandon NJ, Wang Q, Dekker N, Jawhari A. Agez M, et al. Among authors: baker dj. Sci Rep. 2017 Nov 28;7(1):16452. doi: 10.1038/s41598-017-15739-1. Sci Rep. 2017. PMID: 29184062 Free PMC article.
Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly.
Ouberai MM, Dos Santos ALG, Kinna S, Madalli S, Hornigold DC, Baker D, Naylor J, Sheldrake L, Corkill DJ, Hood J, Vicini P, Uddin S, Bishop S, Varley PG, Welland ME. Ouberai MM, et al. Among authors: baker d. Nat Commun. 2017 Oct 18;8(1):1026. doi: 10.1038/s41467-017-01114-1. Nat Commun. 2017. PMID: 29044101 Free PMC article.
Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice.
Galvin SG, Larraufie P, Kay RG, Pitt H, Bernard E, McGavigan AK, Brant H, Hood J, Sheldrake L, Conder S, Atherton-Kemp D, Lu VB, O'Flaherty EAA, Roberts GP, Ämmälä C, Jermutus L, Baker D, Gribble FM, Reimann F. Galvin SG, et al. Peptides. 2021 Jun;140:170532. doi: 10.1016/j.peptides.2021.170532. Epub 2021 Mar 17. Peptides. 2021. PMID: 33744371 Free PMC article.
Stimulating intestinal GIP release reduces food intake and body weight in mice.
Lewis JE, Nuzzaci D, James-Okoro PP, Montaner M, O'Flaherty E, Darwish T, Hayashi M, Liberles SD, Hornigold D, Naylor J, Baker D, Gribble FM, Reimann F. Lewis JE, et al. Mol Metab. 2024 Jun;84:101945. doi: 10.1016/j.molmet.2024.101945. Epub 2024 Apr 21. Mol Metab. 2024. PMID: 38653401 Free PMC article.
292 results