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The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity.
Cardarelli RA, Jones K, Pisella LI, Wobst HJ, McWilliams LJ, Sharpe PM, Burnham MP, Baker DJ, Chudotvorova I, Guyot J, Silayeva L, Morrow DH, Dekker N, Zicha S, Davies PA, Holenz J, Duggan ME, Dunlop J, Mather RJ, Wang Q, Medina I, Brandon NJ, Deeb TZ, Moss SJ. Cardarelli RA, et al. Among authors: wang q. Nat Med. 2017 Dec 7;23(12):1394-1396. doi: 10.1038/nm.4442. Nat Med. 2017. PMID: 29216042 Free PMC article. No abstract available.
How has DISC1 enabled drug discovery?
Wang Q, Jaaro-Peled H, Sawa A, Brandon NJ. Wang Q, et al. Mol Cell Neurosci. 2008 Feb;37(2):187-95. doi: 10.1016/j.mcn.2007.10.006. Epub 2007 Oct 23. Mol Cell Neurosci. 2008. PMID: 18055216 Review.
Regulation of N-methyl-D-aspartate receptors by disrupted-in-schizophrenia-1.
Wei J, Graziane NM, Wang H, Zhong P, Wang Q, Liu W, Hayashi-Takagi A, Korth C, Sawa A, Brandon NJ, Yan Z. Wei J, et al. Among authors: wang h, wang q. Biol Psychiatry. 2014 Mar 1;75(5):414-424. doi: 10.1016/j.biopsych.2013.06.009. Epub 2013 Jul 29. Biol Psychiatry. 2014. PMID: 23906531 Free PMC article.
Organization of TNIK in dendritic spines.
Burette AC, Phend KD, Burette S, Lin Q, Liang M, Foltz G, Taylor N, Wang Q, Brandon NJ, Bates B, Ehlers MD, Weinberg RJ. Burette AC, et al. Among authors: wang q. J Comp Neurol. 2015 Sep 1;523(13):1913-24. doi: 10.1002/cne.23770. Epub 2015 Jul 1. J Comp Neurol. 2015. PMID: 25753355 Free PMC article.
Molecular architecture of potassium chloride co-transporter KCC2.
Agez M, Schultz P, Medina I, Baker DJ, Burnham MP, Cardarelli RA, Conway LC, Garnier K, Geschwindner S, Gunnarsson A, McCall EJ, Frechard A, Audebert S, Deeb TZ, Moss SJ, Brandon NJ, Wang Q, Dekker N, Jawhari A. Agez M, et al. Among authors: wang q. Sci Rep. 2017 Nov 28;7(1):16452. doi: 10.1038/s41598-017-15739-1. Sci Rep. 2017. PMID: 29184062 Free PMC article.
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