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Page 1
Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.
Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, Cagnone G, Blot G, Hafiane I, Dejda A, Rizk R, Juneau R, Buscarlet M, Chorfi S, Patel P, Beltran PJ, Joyal JS, Rezende FA, Hata M, Nguyen A, Sullivan L, Damiano J, Wilson AM, Mallette FA, David NE, Ghosh A, Tsuruda PR, Dananberg J, Sapieha P. Crespo-Garcia S, et al. Among authors: tsuruda pr. Nat Med. 2024 Feb;30(2):443-454. doi: 10.1038/s41591-024-02802-4. Epub 2024 Feb 6. Nat Med. 2024. PMID: 38321220 Clinical Trial.
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.
Crespo-Garcia S, Tsuruda PR, Dejda A, Ryan RD, Fournier F, Chaney SY, Pilon F, Dogan T, Cagnone G, Patel P, Buscarlet M, Dasgupta S, Girouard G, Rao SR, Wilson AM, O'Brien R, Juneau R, Guber V, Dubrac A, Beausejour C, Armstrong S, Mallette FA, Yohn CB, Joyal JS, Marquess D, Beltran PJ, Sapieha P. Crespo-Garcia S, et al. Among authors: tsuruda pr. Cell Metab. 2021 Apr 6;33(4):818-832.e7. doi: 10.1016/j.cmet.2021.01.011. Epub 2021 Feb 5. Cell Metab. 2021. PMID: 33548171 Free article.
Discovery of Axelopran (TD-1211): A Peripherally Restricted μ-Opioid Receptor Antagonist.
Long DD, Armstrong SR, Beattie DT, Campbell CB, Church TJ, Colson PJ, Dalziel SM, Jacobsen JR, Jiang L, Obedencio GP, Rapta M, Saito D, Stergiades I, Tsuruda PR, Van Dyke PM, Vickery RG. Long DD, et al. Among authors: tsuruda pr. ACS Med Chem Lett. 2019 Nov 26;10(12):1641-1647. doi: 10.1021/acsmedchemlett.9b00406. eCollection 2019 Dec 12. ACS Med Chem Lett. 2019. PMID: 31857840 Free PMC article.
Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor.
Smith JA, Bourdet DL, Daniels OT, Ding YS, Gallezot JD, Henry S, Kim KH, Kshirsagar S, Martin WJ, Obedencio GP, Stangeland E, Tsuruda PR, Williams W, Carson RE, Patil ST. Smith JA, et al. Among authors: tsuruda pr. Int J Neuropsychopharmacol. 2014 Dec 13;18(2):pyu027. doi: 10.1093/ijnp/pyu027. Int J Neuropsychopharmacol. 2014. PMID: 25522383 Free PMC article.
The star-nosed mole reveals clues to the molecular basis of mammalian touch.
Gerhold KA, Pellegrino M, Tsunozaki M, Morita T, Leitch DB, Tsuruda PR, Brem RB, Catania KC, Bautista DM. Gerhold KA, et al. Among authors: tsuruda pr. PLoS One. 2013;8(1):e55001. doi: 10.1371/journal.pone.0055001. Epub 2013 Jan 30. PLoS One. 2013. PMID: 23383028 Free PMC article.
20 results