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Page 1
The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
Barbier-Torres L, Iruzubieta P, Fernández-Ramos D, Delgado TC, Taibo D, Guitiérrez-de-Juan V, Varela-Rey M, Azkargorta M, Navasa N, Fernández-Tussy P, Zubiete-Franco I, Simon J, Lopitz-Otsoa F, Lachiondo-Ortega S, Crespo J, Masson S, McCain MV, Villa E, Reeves H, Elortza F, Lucena MI, Hernández-Alvarez MI, Zorzano A, Andrade RJ, Lu SC, Mato JM, Anguita J, Rincón M, Martínez-Chantar ML. Barbier-Torres L, et al. Nat Commun. 2017 Dec 12;8(1):2068. doi: 10.1038/s41467-017-01970-x. Nat Commun. 2017. PMID: 29233977 Free PMC article.
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity.
Hernández-Alvarez MI, Thabit H, Burns N, Shah S, Brema I, Hatunic M, Finucane F, Liesa M, Chiellini C, Naon D, Zorzano A, Nolan JJ. Hernández-Alvarez MI, et al. Diabetes Care. 2010 Mar;33(3):645-51. doi: 10.2337/dc09-1305. Epub 2009 Dec 23. Diabetes Care. 2010. PMID: 20032281 Free PMC article. Clinical Trial.
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis.
Sebastián D, Hernández-Alvarez MI, Segalés J, Sorianello E, Muñoz JP, Sala D, Waget A, Liesa M, Paz JC, Gopalacharyulu P, Orešič M, Pich S, Burcelin R, Palacín M, Zorzano A. Sebastián D, et al. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5523-8. doi: 10.1073/pnas.1108220109. Epub 2012 Mar 16. Proc Natl Acad Sci U S A. 2012. PMID: 22427360 Free PMC article.
Mfn2 modulates the UPR and mitochondrial function via repression of PERK.
Muñoz JP, Ivanova S, Sánchez-Wandelmer J, Martínez-Cristóbal P, Noguera E, Sancho A, Díaz-Ramos A, Hernández-Alvarez MI, Sebastián D, Mauvezin C, Palacín M, Zorzano A. Muñoz JP, et al. EMBO J. 2013 Aug 28;32(17):2348-61. doi: 10.1038/emboj.2013.168. Epub 2013 Aug 6. EMBO J. 2013. PMID: 23921556 Free PMC article.
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway.
Sebastián D, Sorianello E, Segalés J, Irazoki A, Ruiz-Bonilla V, Sala D, Planet E, Berenguer-Llergo A, Muñoz JP, Sánchez-Feutrie M, Plana N, Hernández-Álvarez MI, Serrano AL, Palacín M, Zorzano A. Sebastián D, et al. EMBO J. 2016 Aug 1;35(15):1677-93. doi: 10.15252/embj.201593084. Epub 2016 Jun 22. EMBO J. 2016. PMID: 27334614 Free PMC article.
35 results