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In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.
Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh PJ, Schofield CJ, Fishwick CWG. Cain R, et al. Among authors: lee sy. J Med Chem. 2018 Feb 8;61(3):1255-1260. doi: 10.1021/acs.jmedchem.7b01728. Epub 2018 Jan 10. J Med Chem. 2018. PMID: 29271657 Free article.
Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.
Sengerová B, Allerston CK, Abu M, Lee SY, Hartley J, Kiakos K, Schofield CJ, Hartley JA, Gileadi O, McHugh PJ. Sengerová B, et al. Among authors: lee sy. J Biol Chem. 2012 Jul 27;287(31):26254-67. doi: 10.1074/jbc.M112.367243. Epub 2012 Jun 11. J Biol Chem. 2012. PMID: 22692201 Free PMC article.
CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.
Iyama T, Lee SY, Berquist BR, Gileadi O, Bohr VA, Seidman MM, McHugh PJ, Wilson DM 3rd. Iyama T, et al. Among authors: lee sy. Nucleic Acids Res. 2015 Jan;43(1):247-58. doi: 10.1093/nar/gku1279. Epub 2014 Dec 10. Nucleic Acids Res. 2015. PMID: 25505141 Free PMC article.
Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers.
Brem J, van Berkel SS, Zollman D, Lee SY, Gileadi O, McHugh PJ, Walsh TR, McDonough MA, Schofield CJ. Brem J, et al. Among authors: lee sy. Antimicrob Agents Chemother. 2015 Oct 19;60(1):142-50. doi: 10.1128/AAC.01335-15. Print 2016 Jan. Antimicrob Agents Chemother. 2015. PMID: 26482303 Free PMC article.
The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins.
Pettinati I, Brem J, Lee SY, McHugh PJ, Schofield CJ. Pettinati I, et al. Among authors: lee sy. Trends Biochem Sci. 2016 Apr;41(4):338-355. doi: 10.1016/j.tibs.2015.12.007. Epub 2016 Jan 21. Trends Biochem Sci. 2016. PMID: 26805042 Free PMC article. Review.
A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.
Doherty W, Dürr EM, Baddock HT, Lee SY, McHugh PJ, Brown T, Senge MO, Scanlan EM, McGouran JF. Doherty W, et al. Among authors: lee sy. Org Biomol Chem. 2019 Sep 21;17(35):8094-8105. doi: 10.1039/c9ob01133a. Epub 2019 Aug 5. Org Biomol Chem. 2019. PMID: 31380542 Free PMC article.
SNM1A is crucial for efficient repair of complex DNA breaks in human cells.
Swift LP, Lagerholm BC, Henderson LR, Ratnaweera M, Baddock HT, Sengerova B, Lee S, Cruz-Migoni A, Waithe D, Renz C, Ulrich HD, Newman JA, Schofield CJ, McHugh PJ. Swift LP, et al. Nat Commun. 2024 Jun 25;15(1):5392. doi: 10.1038/s41467-024-49583-5. Nat Commun. 2024. PMID: 38918391 Free PMC article.
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