Roush W - Search Results

1

Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors.

Monastyrskyi A, Bayle S, Quereda V, Grant W, Cameron M, Duckett D, Roush W. Monastyrskyi A, et al. Among authors: roush w. Bioorg Med Chem Lett. 2018 Feb 1;28(3):400-404. doi: 10.1016/j.bmcl.2017.12.026. Epub 2017 Dec 13. Bioorg Med Chem Lett. 2018. PMID: 29277458 Free PMC article.

2

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain.

Roush WR, Cheng J, Knapp-Reed B, Alvarez-Hernandez A, McKerrow JH, Hansell E, Engel JC. Roush WR, et al. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2759-62. doi: 10.1016/s0960-894x(01)00566-2. Bioorg Med Chem Lett. 2001. PMID: 11591518

3

Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds.

Roth J, Madoux F, Hodder P, Roush WR. Roth J, et al. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2628-32. doi: 10.1016/j.bmcl.2008.03.027. Epub 2008 Mar 14. Bioorg Med Chem Lett. 2008. PMID: 18374567 Free PMC article.

4

Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.

Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR. Chen YT, et al. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5860-3. doi: 10.1016/j.bmcl.2008.06.012. Epub 2008 Jun 10. Bioorg Med Chem Lett. 2008. PMID: 18585034 Free PMC article.

5

Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist.

Kumar N, Kojetin DJ, Solt LA, Kumar KG, Nuhant P, Duckett DR, Cameron MD, Butler AA, Roush WR, Griffin PR, Burris TP. Kumar N, et al. ACS Chem Biol. 2011 Mar 18;6(3):218-22. doi: 10.1021/cb1002762. Epub 2010 Dec 6. ACS Chem Biol. 2011. PMID: 21090593 Free PMC article.

6

Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors.

Busby SA, Kumar N, Kuruvilla DS, Istrate MA, Conkright JJ, Wang Y, Kamenecka TM, Cameron MD, Roush WR, Burris TP, Griffin PR. Busby SA, et al. ACS Chem Biol. 2011 Jun 17;6(6):618-27. doi: 10.1021/cb100396s. Epub 2011 Mar 17. ACS Chem Biol. 2011. PMID: 21381756 Free PMC article.

7

Chemistry and biology of macrolide antiparasitic agents.

Lee Y, Choi JY, Fu H, Harvey C, Ravindran S, Roush WR, Boothroyd JC, Khosla C. Lee Y, et al. J Med Chem. 2011 Apr 28;54(8):2792-804. doi: 10.1021/jm101593u. Epub 2011 Mar 23. J Med Chem. 2011. PMID: 21428405 Free PMC article.

8

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

Roth J, Minond D, Darout E, Liu Q, Lauer J, Hodder P, Fields GB, Roush WR. Roth J, et al. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7180-4. doi: 10.1016/j.bmcl.2011.09.077. Epub 2011 Sep 22. Bioorg Med Chem Lett. 2011. PMID: 22018790 Free PMC article.

9

Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.

Choi JY, Plummer MS, Starr J, Desbonnet CR, Soutter H, Chang J, Miller JR, Dillman K, Miller AA, Roush WR. Choi JY, et al. J Med Chem. 2012 Jan 26;55(2):852-70. doi: 10.1021/jm201349f. Epub 2012 Jan 13. J Med Chem. 2012. PMID: 22243413 Free PMC article.

10

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties.

Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR. Bibian M, et al. Among authors: roush wr. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. Epub 2013 May 31. Bioorg Med Chem Lett. 2013. PMID: 23787102 Free PMC article.

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