Iwatsubo T - Search Results

1

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.

Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T. Kidana K, et al. Among authors: iwatsubo t. EMBO Mol Med. 2018 Mar;10(3):e8184. doi: 10.15252/emmm.201708184. EMBO Mol Med. 2018. PMID: 29311134 Free PMC article.

2

Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.

Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T. Morohashi Y, et al. Among authors: iwatsubo t. J Biol Chem. 2002 Apr 26;277(17):14965-75. doi: 10.1074/jbc.M200897200. Epub 2002 Feb 14. J Biol Chem. 2002. PMID: 11847232 Free article.

3

CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV.

Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T. Hashimoto T, et al. Among authors: iwatsubo t. EMBO J. 2002 Apr 2;21(7):1524-34. doi: 10.1093/emboj/21.7.1524. EMBO J. 2002. PMID: 11927537 Free PMC article.

4

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

Tomita T, Katayama R, Takikawa R, Iwatsubo T. Tomita T, et al. Among authors: iwatsubo t. FEBS Lett. 2002 Jun 5;520(1-3):117-21. doi: 10.1016/s0014-5793(02)02802-8. FEBS Lett. 2002. PMID: 12044882 Free article.

5

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Okochi M, et al. Among authors: iwatsubo t. EMBO J. 2002 Oct 15;21(20):5408-16. doi: 10.1093/emboj/cdf541. EMBO J. 2002. PMID: 12374741 Free PMC article.

6

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals.

Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T. Takasugi N, et al. Among authors: iwatsubo t. J Biol Chem. 2002 Dec 20;277(51):50198-205. doi: 10.1074/jbc.M205352200. Epub 2002 Oct 17. J Biol Chem. 2002. PMID: 12388554 Free article.

7

[The mechanism of A beta production and its inhibition as a therapeutic strategy for the prevention of Alzheimer's disease].

Iwatsubo T. Iwatsubo T. Nihon Yakurigaku Zasshi. 2002 Nov;120(1):30P-33P. Nihon Yakurigaku Zasshi. 2002. PMID: 12491772 Review. Japanese.

8

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Murakami D, et al. Among authors: iwatsubo t. Oncogene. 2003 Mar 13;22(10):1511-6. doi: 10.1038/sj.onc.1206298. Oncogene. 2003. PMID: 12629514

9

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation.

Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. Takahashi Y, et al. Among authors: iwatsubo t. J Biol Chem. 2003 May 16;278(20):18664-70. doi: 10.1074/jbc.M301619200. Epub 2003 Mar 10. J Biol Chem. 2003. PMID: 12637581 Free article.

10

The role of presenilin cofactors in the gamma-secretase complex.

Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. Takasugi N, et al. Among authors: iwatsubo t. Nature. 2003 Mar 27;422(6930):438-41. doi: 10.1038/nature01506. Epub 2003 Mar 16. Nature. 2003. PMID: 12660785

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