Hotta A - Search Results

1

Site-specific randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in human cells.

Ishida K, Xu H, Sasakawa N, Lung MSY, Kudryashev JA, Gee P, Hotta A. Ishida K, et al. Among authors: hotta a. Sci Rep. 2018 Jan 10;8(1):310. doi: 10.1038/s41598-017-18568-4. Sci Rep. 2018. PMID: 29321585 Free PMC article.

2

Delivery of full-length factor VIII using a piggyBac transposon vector to correct a mouse model of hemophilia A.

Matsui H, Fujimoto N, Sasakawa N, Ohinata Y, Shima M, Yamanaka S, Sugimoto M, Hotta A. Matsui H, et al. Among authors: hotta a. PLoS One. 2014 Aug 15;9(8):e104957. doi: 10.1371/journal.pone.0104957. eCollection 2014. PLoS One. 2014. PMID: 25126862 Free PMC article.

3

Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9.

Li HL, Fujimoto N, Sasakawa N, Shirai S, Ohkame T, Sakuma T, Tanaka M, Amano N, Watanabe A, Sakurai H, Yamamoto T, Yamanaka S, Hotta A. Li HL, et al. Among authors: hotta a. Stem Cell Reports. 2015 Jan 13;4(1):143-154. doi: 10.1016/j.stemcr.2014.10.013. Epub 2014 Nov 26. Stem Cell Reports. 2015. PMID: 25434822 Free PMC article.

4

From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing.

Hotta A, Yamanaka S. Hotta A, et al. Annu Rev Genet. 2015;49:47-70. doi: 10.1146/annurev-genet-112414-054926. Epub 2015 Sep 25. Annu Rev Genet. 2015. PMID: 26407033 Review.

5

Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases.

Ishida K, Gee P, Hotta A. Ishida K, et al. Among authors: hotta a. Int J Mol Sci. 2015 Oct 16;16(10):24751-71. doi: 10.3390/ijms161024751. Int J Mol Sci. 2015. PMID: 26501275 Free PMC article. Review.

6

Efficient genomic correction methods in human iPS cells using CRISPR-Cas9 system.

Li HL, Gee P, Ishida K, Hotta A. Li HL, et al. Among authors: hotta a. Methods. 2016 May 15;101:27-35. doi: 10.1016/j.ymeth.2015.10.015. Epub 2015 Oct 23. Methods. 2016. PMID: 26525194 Free article. Review.

7

Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons.

Imamura K, Sahara N, Kanaan NM, Tsukita K, Kondo T, Kutoku Y, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski JQ, Lee VM, Suhara T, Higuchi M, Inoue H. Imamura K, et al. Among authors: hotta a. Sci Rep. 2016 Oct 10;6:34904. doi: 10.1038/srep34904. Sci Rep. 2016. PMID: 27721502 Free PMC article.

8

Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch.

Hirosawa M, Fujita Y, Parr CJC, Hayashi K, Kashida S, Hotta A, Woltjen K, Saito H. Hirosawa M, et al. Among authors: hotta a. Nucleic Acids Res. 2017 Jul 27;45(13):e118. doi: 10.1093/nar/gkx309. Nucleic Acids Res. 2017. PMID: 28525578 Free PMC article.

9

Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy.

Gee P, Xu H, Hotta A. Gee P, et al. Among authors: hotta a. Stem Cells Int. 2017;2017:8765154. doi: 10.1155/2017/8765154. Epub 2017 May 15. Stem Cells Int. 2017. PMID: 28607562 Free PMC article. Review.

10

Restoration of Dystrophin Protein Expression by Exon Skipping Utilizing CRISPR-Cas9 in Myoblasts Derived from DMD Patient iPS Cells.

Ifuku M, Iwabuchi KA, Tanaka M, Lung MSY, Hotta A. Ifuku M, et al. Among authors: hotta a. Methods Mol Biol. 2018;1828:191-217. doi: 10.1007/978-1-4939-8651-4_12. Methods Mol Biol. 2018. PMID: 30171543

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