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Page 1
Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.
Ting JP, Tung F, Antonysamy S, Wasserman S, Jones SB, Zhang FF, Espada A, Broughton H, Chalmers MJ, Woodman ME, Bina HA, Dodge JA, Benach J, Zhang A, Groshong C, Manglicmot D, Russell M, Afshar S. Ting JP, et al. Among authors: bina ha. PLoS One. 2018 Jan 12;13(1):e0190850. doi: 10.1371/journal.pone.0190850. eCollection 2018. PLoS One. 2018. PMID: 29329326 Free PMC article.
Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).
Lugar CW, Clarke CA, Morphy R, Rudyk H, Sapmaz S, Stites RE, Vaught GM, Furness K, Broughton HB, Durst GL, Clawson DK, Stout SL, Guo SY, Durbin JD, Stayrook KR, Edmondson DD, Kikly K, New NE, Bina HA, Chambers MG, Shetler P, Chang WY, Chang VC, Barr R, Gough WH, Steele JP, Getman B, Patel N, Mathes BM, Richardson TI. Lugar CW, et al. Among authors: bina ha. J Med Chem. 2021 May 13;64(9):5470-5484. doi: 10.1021/acs.jmedchem.0c01918. Epub 2021 Apr 14. J Med Chem. 2021. PMID: 33852312
Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease.
Benschop RJ, Chow CK, Tian Y, Nelson J, Barmettler B, Atwell S, Clawson D, Chai Q, Jones B, Fitchett J, Torgerson S, Ji Y, Bina H, Hu N, Ghanem M, Manetta J, Wroblewski VJ, Lu J, Allan BW. Benschop RJ, et al. MAbs. 2019 Aug/Sep;11(6):1175-1190. doi: 10.1080/19420862.2019.1624463. Epub 2019 Jun 10. MAbs. 2019. PMID: 31181988 Free PMC article.
Fundamentals of FGF19 & FGF21 action in vitro and in vivo.
Adams AC, Coskun T, Rovira AR, Schneider MA, Raches DW, Micanovic R, Bina HA, Dunbar JD, Kharitonenkov A. Adams AC, et al. Among authors: bina ha. PLoS One. 2012;7(5):e38438. doi: 10.1371/journal.pone.0038438. Epub 2012 May 31. PLoS One. 2012. PMID: 22675463 Free PMC article.
FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho.
Kharitonenkov A, Dunbar JD, Bina HA, Bright S, Moyers JS, Zhang C, Ding L, Micanovic R, Mehrbod SF, Knierman MD, Hale JE, Coskun T, Shanafelt AB. Kharitonenkov A, et al. Among authors: bina ha. J Cell Physiol. 2008 Apr;215(1):1-7. doi: 10.1002/jcp.21357. J Cell Physiol. 2008. PMID: 18064602
Fibroblast growth factor 21 corrects obesity in mice.
Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y, Moller DE, Kharitonenkov A. Coskun T, et al. Among authors: bina ha. Endocrinology. 2008 Dec;149(12):6018-27. doi: 10.1210/en.2008-0816. Epub 2008 Aug 7. Endocrinology. 2008. PMID: 18687777
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