Rare Variants in Specific Lysosomal Genes Are Associated With Parkinson's Disease.
Hopfner F, Mueller SH, Szymczak S, Junge O, Tittmann L, May S, Lohmann K, Grallert H, Lieb W, Strauch K, Müller-Nurasyid M, Berger K, Schormair B, Winkelmann J, Mollenhauer B, Trenkwalder C, Maetzler W, Berg D, Kasten M, Klein C, Höglinger GU, Gasser T, Deuschl G, Franke A, Krawczak M, Dempfle A, Kuhlenbäumer G.
Hopfner F, et al. Among authors: may s.
Mov Disord. 2020 Jul;35(7):1245-1248. doi: 10.1002/mds.28037. Epub 2020 Apr 8.
Mov Disord. 2020.
PMID: 32267580
OBJECTIVE: Impaired lysosomal degradation of alpha-synuclein and other cellular constituents may play an important role in Parkinson's disease (PD). Rare genetic variants in the glucocerebrosidase (GBA) gene were consistently associated with PD. ...
OBJECTIVE: Impaired lysosomal degradation of alpha-synuclein and other cellular constituents may play an important role in Parkinson' …