Law BJC - Search Results

1

Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase.

Law BJC, Struck AW, Bennett MR, Wilkinson B, Micklefield J. Law BJC, et al. Chem Sci. 2015 May 1;6(5):2885-2892. doi: 10.1039/c5sc00164a. Epub 2015 Mar 2. Chem Sci. 2015. PMID: 29403635 Free PMC article.

2

An Enzyme Cascade for Selective Modification of Tyrosine Residues in Structurally Diverse Peptides and Proteins.

Struck AW, Bennett MR, Shepherd SA, Law BJ, Zhuo Y, Wong LS, Micklefield J. Struck AW, et al. J Am Chem Soc. 2016 Mar 9;138(9):3038-45. doi: 10.1021/jacs.5b10928. Epub 2016 Feb 25. J Am Chem Soc. 2016. PMID: 26867114 Free article.

3

Engineered biosynthesis of enduracidin lipoglycopeptide antibiotics using the ramoplanin mannosyltransferase Ram29.

Wu MC, Styles MQ, Law BJ, Struck AW, Nunns L, Micklefield J. Wu MC, et al. Microbiology (Reading). 2015 Jul;161(7):1338-47. doi: 10.1099/mic.0.000095. Epub 2015 Apr 15. Microbiology (Reading). 2015. PMID: 25878261 Free PMC article.

4

Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase.

Law BJ, Bennett MR, Thompson ML, Levy C, Shepherd SA, Leys D, Micklefield J. Law BJ, et al. Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2683-7. doi: 10.1002/anie.201508287. Epub 2016 Jan 21. Angew Chem Int Ed Engl. 2016. PMID: 26797714 Free PMC article.

5

Bioengineering natural product biosynthetic pathways for therapeutic applications.

Wu MC, Law B, Wilkinson B, Micklefield J. Wu MC, et al. Curr Opin Biotechnol. 2012 Dec;23(6):931-40. doi: 10.1016/j.copbio.2012.03.008. Epub 2012 Apr 7. Curr Opin Biotechnol. 2012. PMID: 22487048 Review.

6

A Flavin-Dependent Decarboxylase-Dehydrogenase-Monooxygenase Assembles the Warhead of α,β-Epoxyketone Proteasome Inhibitors.

Zabala D, Cartwright JW, Roberts DM, Law BJ, Song L, Samborskyy M, Leadlay PF, Micklefield J, Challis GL. Zabala D, et al. J Am Chem Soc. 2016 Apr 6;138(13):4342-5. doi: 10.1021/jacs.6b01619. Epub 2016 Mar 25. J Am Chem Soc. 2016. PMID: 26999044

7

Gene editing enables rapid engineering of complex antibiotic assembly lines.

Thong WL, Zhang Y, Zhuo Y, Robins KJ, Fyans JK, Herbert AJ, Law BJC, Micklefield J. Thong WL, et al. Among authors: law bjc. Nat Commun. 2021 Nov 25;12(1):6872. doi: 10.1038/s41467-021-27139-1. Nat Commun. 2021. PMID: 34824225 Free PMC article.

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