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Discovery of NV-5138, the first selective Brain mTORC1 activator.
Sengupta S, Giaime E, Narayan S, Hahm S, Howell J, O'Neill D, Vlasuk GP, Saiah E. Sengupta S, et al. Among authors: vlasuk gp. Sci Rep. 2019 Mar 11;9(1):4107. doi: 10.1038/s41598-019-40693-5. Sci Rep. 2019. PMID: 30858438 Free PMC article.
Modulation of nutrient sensing nuclear hormone receptors promotes weight loss through appetite suppression in mice.
Perreault M, Will S, Panza D, Gareski T, Harding K, Kubasiak D, Jalenak M, Gartrell K, Wang S, Bollag G, Artis DR, Ibrahim PN, Womack P, Lin JJ, Saiah E, Mansour TS, Vlasuk GP, Erbe DV, Tobin JF. Perreault M, et al. Among authors: vlasuk gp. Diabetes Obes Metab. 2010 Mar;12(3):234-45. doi: 10.1111/j.1463-1326.2009.01157.x. Diabetes Obes Metab. 2010. PMID: 20152000
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Dai H, Case AW, Riera TV, Considine T, Lee JE, Hamuro Y, Zhao H, Jiang Y, Sweitzer SM, Pietrak B, Schwartz B, Blum CA, Disch JS, Caldwell R, Szczepankiewicz B, Oalmann C, Yee Ng P, White BH, Casaubon R, Narayan R, Koppetsch K, Bourbonais F, Wu B, Wang J, Qian D, Jiang F, Mao C, Wang M, Hu E, Wu JC, Perni RB, Vlasuk GP, Ellis JL. Dai H, et al. Among authors: vlasuk gp. Nat Commun. 2015 Jul 2;6:7645. doi: 10.1038/ncomms8645. Nat Commun. 2015. PMID: 26134520 Free PMC article.
US immigration order strikes against biotech.
Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forrester R, Francois C, Franklin H, Freeman MW, Furst H, Gage LP, Galakatos N, Gallagher BM, Geraghty JA, Gill S, Goeddel DV, Goldsmith MA, Gowen M, Goyal V, Graney T, Grayzel D, Greene B, Grint P, Gutierrez-Ramos JC, Haney B, Ha-Ngoc T, Harris T, Hasnain F, Hata YS, Hecht P, Henshaw L, Heyman R, Hoppenot H, Horvitz HR, Hughes TE, Hutton WS, Isaacs ST, Jenkins A, Jonker J, Kaplan J, Karsen P, Keiper J, Kim J, Kindler J, King R, King V, Kjellson N, Koenig S, Koenig G, Kolchinsky P, Laikind P, Langer RB, Lee JJ, Leff JS, Leicher BA, Leschly N, Levin A, Levin M, Levine AJ, Levy A, Liu DR, Lodish HF, Lopatin U, Love TW, Macdonald G, Maderis GJ, Mahadevia A, Mahanthappa NK, Martin JF, Martin A, Martucci… See abstract for full author list ➔ Levin JM, et al. Among authors: vlasuk gp. Nat Biotechnol. 2017 Mar 7;35(3):204-206. doi: 10.1038/nbt.3824. Nat Biotechnol. 2017. PMID: 28267733 No abstract available.
APJ acts as a dual receptor in cardiac hypertrophy.
Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE, Purcell NH, Catalucci D, Akasaka T, Bueno OF, Vlasuk GP, Kaliman P, Bodmer R, Smith LH, Ashley E, Mercola M, Brown JH, Ruiz-Lozano P. Scimia MC, et al. Among authors: vlasuk gp. Nature. 2012 Aug 16;488(7411):394-8. doi: 10.1038/nature11263. Nature. 2012. PMID: 22810587 Free PMC article.
Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent.
Artis DR, Lin JJ, Zhang C, Wang W, Mehra U, Perreault M, Erbe D, Krupka HI, England BP, Arnold J, Plotnikov AN, Marimuthu A, Nguyen H, Will S, Signaevsky M, Kral J, Cantwell J, Settachatgull C, Yan DS, Fong D, Oh A, Shi S, Womack P, Powell B, Habets G, West BL, Zhang KY, Milburn MV, Vlasuk GP, Hirth KP, Nolop K, Bollag G, Ibrahim PN, Tobin JF. Artis DR, et al. Among authors: vlasuk gp. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):262-7. doi: 10.1073/pnas.0811325106. Epub 2008 Dec 30. Proc Natl Acad Sci U S A. 2009. PMID: 19116277 Free PMC article.
120 results