Chen L - Search Results

1

6,7-Dimorpholinoalkoxy quinazoline derivatives as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells.

Zhang Y, Chen L, Xu H, Li X, Zhao L, Wang W, Li B, Zhang X. Zhang Y, et al. Among authors: chen l. Eur J Med Chem. 2018 Mar 10;147:77-89. doi: 10.1016/j.ejmech.2018.01.090. Epub 2018 Feb 1. Eur J Med Chem. 2018. PMID: 29421573

2

Novel 4-arylaminoquinazoline derivatives with (E)-propen-1-yl moiety as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells.

Chen L, Zhang Y, Liu J, Wang W, Li X, Zhao L, Wang W, Li B. Chen L, et al. Eur J Med Chem. 2017 Sep 29;138:689-697. doi: 10.1016/j.ejmech.2017.06.023. Epub 2017 Jun 13. Eur J Med Chem. 2017. PMID: 28711703

3

Quinazoline-1-deoxynojirimycin hybrids as high active dual inhibitors of EGFR and α-glucosidase.

Zhang Y, Gao H, Liu R, Liu J, Chen L, Li X, Zhao L, Wang W, Li B. Zhang Y, et al. Among authors: chen l. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4309-4313. doi: 10.1016/j.bmcl.2017.08.035. Epub 2017 Aug 18. Bioorg Med Chem Lett. 2017. PMID: 28838691

4

Novel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFR^wt-TK inhibitor.

Zhang Y, Chen L, Li X, Gao L, Hao Y, Li B, Yan Y. Zhang Y, et al. Among authors: chen l. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1668-1677. doi: 10.1080/14756366.2019.1667341. J Enzyme Inhib Med Chem. 2019. PMID: 31530043 Free PMC article.

5

Discovery of novel NO-releasing celastrol derivatives with Hsp90 inhibition and cytotoxic activities.

Li N, Xu M, Bao N, Shi W, Li Q, Zhang X, Sun J, Chen L. Li N, et al. Among authors: chen l. Eur J Med Chem. 2018 Dec 5;160:1-8. doi: 10.1016/j.ejmech.2018.10.013. Epub 2018 Oct 6. Eur J Med Chem. 2018. PMID: 30316059

6

Design, synthesis and antitumor evaluation of novel celastrol derivatives.

Xu M, Li N, Zhao Z, Shi Z, Sun J, Chen L. Xu M, et al. Among authors: chen l. Eur J Med Chem. 2019 Jul 15;174:265-276. doi: 10.1016/j.ejmech.2019.04.050. Epub 2019 Apr 21. Eur J Med Chem. 2019. PMID: 31051401

7

O²-(2,4-dinitrophenyl)diazeniumdiolates derivatives: Design, synthesis, cytotoxic evaluation and reversing MDR in MCF-7/ADR cells.

Li Q, Zou P, Sun J, Chen L. Li Q, et al. Among authors: chen l. Eur J Med Chem. 2018 Jan 1;143:732-744. doi: 10.1016/j.ejmech.2017.11.081. Eur J Med Chem. 2018. PMID: 29220794

8

Novel anticancer hybrids from diazen-1-ium-1,2-diolate nitric oxide donor and ROS inducer plumbagin: Design, synthesis and biological evaluations.

Bao N, Ou J, Li N, Zou P, Sun J, Chen L. Bao N, et al. Among authors: chen l. Eur J Med Chem. 2018 Jun 25;154:1-8. doi: 10.1016/j.ejmech.2018.04.047. Epub 2018 Apr 25. Eur J Med Chem. 2018. PMID: 29772386

9

Novel NO-releasing scopoletin derivatives induce cell death via mitochondrial apoptosis pathway and cell cycle arrest.

Shi Z, Li N, Chen C, Wang Y, Lei Z, Chen L, Sun J. Shi Z, et al. Among authors: chen l, chen c. Eur J Med Chem. 2020 Aug 15;200:112386. doi: 10.1016/j.ejmech.2020.112386. Epub 2020 May 6. Eur J Med Chem. 2020. PMID: 32438251

10

Design, synthesis and biological activity evaluation of novel scopoletin-NO donor derivatives against MCF-7 human breast cancer in vitro and in vivo.

Yu N, Li N, Wang K, Deng Q, Lei Z, Sun J, Chen L. Yu N, et al. Among authors: chen l. Eur J Med Chem. 2021 Nov 15;224:113701. doi: 10.1016/j.ejmech.2021.113701. Epub 2021 Jul 21. Eur J Med Chem. 2021. PMID: 34315044

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