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The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis.
Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, Liu Q, Li K, Wang W, Wang H, Xie W, Wang Q, Liu J, Zheng B, Zhang P, Huang S, Shi T, Zhang B, Dang Y, Chen J, O'Malley BW, Moses RE, Wang P, Li L, Xiao J, Hoffmann A, Li X. Xu J, et al. Among authors: zhang b, zhang p, zhang k. Nat Commun. 2016 Feb 22;7:10761. doi: 10.1038/ncomms10761. Nat Commun. 2016. PMID: 26899380 Free PMC article.
REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway.
Jiao C, Li L, Zhang P, Zhang L, Li K, Fang R, Yuan L, Shi K, Pan L, Guo Q, Gao X, Chen G, Xu S, Wang Q, Zuo D, Wu W, Qiao S, Wang X, Moses R, Xiao J, Li L, Dang Y, Li X. Jiao C, et al. Among authors: zhang l, zhang p. Cell Death Differ. 2020 Feb;27(2):497-508. doi: 10.1038/s41418-019-0367-9. Epub 2019 Jun 26. Cell Death Differ. 2020. PMID: 31243343 Free PMC article.
REGγ is associated with multiple oncogenic pathways in human cancers.
He J, Cui L, Zeng Y, Wang G, Zhou P, Yang Y, Ji L, Zhao Y, Chen J, Wang Z, Shi T, Zhang P, Chen R, Li X. He J, et al. Among authors: zhang p. BMC Cancer. 2012 Feb 23;12:75. doi: 10.1186/1471-2407-12-75. BMC Cancer. 2012. PMID: 22361172 Free PMC article.
The proteasome activator REGγ counteracts immunoproteasome expression and autoimmunity.
Yao L, Zhou L, Xuan Y, Zhang P, Wang X, Wang T, Meng T, Xue Y, Ma X, Shah AS, Shang S, Ma X, Xie W, Wang H, Fu Q, Xia Y, Moses RE, Wang H, Li L, Xiao J, Zhang B, Li X. Yao L, et al. Among authors: zhang b, zhang p. J Autoimmun. 2019 Sep;103:102282. doi: 10.1016/j.jaut.2019.05.010. Epub 2019 Jun 4. J Autoimmun. 2019. PMID: 31171475
Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis.
Tong L, Shen S, Huang Q, Fu J, Wang T, Pan L, Zhang P, Chen G, Huang T, Li K, Liu Q, Xie S, Yang X, Moses RE, Li X, Li L. Tong L, et al. Among authors: zhang p. Cell Death Differ. 2020 Jun;27(6):1795-1806. doi: 10.1038/s41418-019-0459-6. Epub 2019 Nov 26. Cell Death Differ. 2020. PMID: 31767934 Free PMC article.
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells.
Gao X, Wang Q, Wang Y, Liu J, Liu S, Liu J, Zhou X, Zhou L, Chen H, Pan L, Chen J, Wang D, Zhang Q, Shen S, Xiao Y, Wu Z, Cheng Y, Chen G, Kubra S, Qin J, Huang L, Zhang P, Wang C, Moses RE, Lonard DM, Malley BWO, Fares F, Zhang B, Li X, Li L, Xiao J. Gao X, et al. Among authors: zhang b, zhang p, zhang q. Nat Commun. 2020 Aug 6;11(1):3904. doi: 10.1038/s41467-020-17667-7. Nat Commun. 2020. PMID: 32764536 Free PMC article.
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