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Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5).
Ahlberg J, Giragossian C, Li H, Myzithras M, Raymond E, Caviness G, Grimaldi C, Brown SE, Perez R, Yang D, Kroe-Barrett R, Joseph D, Pamulapati C, Coble K, Ruus P, Woska JR, Ganesan R, Hansel S, Mbow ML. Ahlberg J, et al. Among authors: kroe barrett r. MAbs. 2019 Jul;11(5):956-964. doi: 10.1080/19420862.2019.1615345. Epub 2019 Jun 4. MAbs. 2019. PMID: 31068073 Free PMC article.
Non-neutralizing antibodies increase endogenous circulating Ang1 levels.
Zheng C, Toth J, Bigwarfe T, MacDougall M, Jerath K, Bovat K, Smith J, Sun P, Hayes D, Fryer R, Singh S, Kroe-Barrett R. Zheng C, et al. MAbs. 2018 Nov-Dec;10(8):1260-1268. doi: 10.1080/19420862.2018.1521130. Epub 2018 Nov 7. MAbs. 2018. PMID: 30199300 Free PMC article.
Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies.
Ganesan R, Raymond EL, Mennerich D, Woska JR Jr, Caviness G, Grimaldi C, Ahlberg J, Perez R, Roberts S, Yang D, Jerath K, Truncali K, Frego L, Sepulveda E, Gupta P, Brown SE, Howell MD, Canada KA, Kroe-Barrett R, Fine JS, Singh S, Mbow ML. Ganesan R, et al. MAbs. 2017 Oct;9(7):1143-1154. doi: 10.1080/19420862.2017.1353853. Epub 2017 Jul 20. MAbs. 2017. PMID: 28726542 Free PMC article.
VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosis.
Low S, Wu H, Jerath K, Tibolla A, Fogal B, Conrad R, MacDougall M, Kerr S, Berger V, Dave R, Villalona J, Pantages L, Ahlberg J, Li H, Van Hoorick D, Ververken C, Broadwater J, Waterman A, Singh S, Kroe-Barrett R. Low S, et al. Among authors: kroe barrett r. MAbs. 2020 Jan-Dec;12(1):1709322. doi: 10.1080/19420862.2019.1709322. MAbs. 2020. PMID: 31924119 Free PMC article.
An optimally designed anti-human CD40 antibody with potent B cell suppression for the treatment of autoimmune diseases.
Wu HH, Ralph KL, Sepuldeva E, Hansen G, Li H, Huang ZF, Liu D, Dziegelewski M, Ahlberg J, Frego L, Fogal S, van Tongeren S, Grimaldi C, Litzenberger T, Presky D, Singh S, Brodeur S, Kroe-Barrett R. Wu HH, et al. Among authors: kroe barrett r. Int J Pharm. 2021 Nov 20;609:121162. doi: 10.1016/j.ijpharm.2021.121162. Epub 2021 Oct 6. Int J Pharm. 2021. PMID: 34624444
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