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Page 1
A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing.
Finn JD, Smith AR, Patel MC, Shaw L, Youniss MR, van Heteren J, Dirstine T, Ciullo C, Lescarbeau R, Seitzer J, Shah RR, Shah A, Ling D, Growe J, Pink M, Rohde E, Wood KM, Salomon WE, Harrington WF, Dombrowski C, Strapps WR, Chang Y, Morrissey DV. Finn JD, et al. Among authors: morrissey dv. Cell Rep. 2018 Feb 27;22(9):2227-2235. doi: 10.1016/j.celrep.2018.02.014. Cell Rep. 2018. PMID: 29490262 Free article.
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.
Hassler MR, Turanov AA, Alterman JF, Haraszti RA, Coles AH, Osborn MF, Echeverria D, Nikan M, Salomon WE, Roux L, Godinho BMDC, Davis SM, Morrissey DV, Zamore PD, Karumanchi SA, Moore MJ, Aronin N, Khvorova A. Hassler MR, et al. Among authors: morrissey dv. Nucleic Acids Res. 2018 Mar 16;46(5):2185-2196. doi: 10.1093/nar/gky037. Nucleic Acids Res. 2018. PMID: 29432571 Free PMC article.
YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.
Fitamant J, Kottakis F, Benhamouche S, Tian HS, Chuvin N, Parachoniak CA, Nagle JM, Perera RM, Lapouge M, Deshpande V, Zhu AX, Lai A, Min B, Hoshida Y, Avruch J, Sia D, Campreciós G, McClatchey AI, Llovet JM, Morrissey D, Raj L, Bardeesy N. Fitamant J, et al. Cell Rep. 2015 Mar 17;10(10):1692-1707. doi: 10.1016/j.celrep.2015.02.027. Epub 2015 Mar 12. Cell Rep. 2015. PMID: 25772357 Free PMC article.
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs.
Morrissey DV, Lockridge JA, Shaw L, Blanchard K, Jensen K, Breen W, Hartsough K, Machemer L, Radka S, Jadhav V, Vaish N, Zinnen S, Vargeese C, Bowman K, Shaffer CS, Jeffs LB, Judge A, MacLachlan I, Polisky B. Morrissey DV, et al. Nat Biotechnol. 2005 Aug;23(8):1002-7. doi: 10.1038/nbt1122. Epub 2005 Jul 24. Nat Biotechnol. 2005. PMID: 16041363 Free article.
Whole-body scanning PCR; a highly sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides.
Boos JA, Kirk DW, Piccolotto ML, Zuercher W, Gfeller S, Neuner P, Dattler A, Wishart WL, Von Arx F, Beverly M, Christensen J, Litherland K, van de Kerkhof E, Swart PJ, Faller T, Beyerbach A, Morrissey D, Hunziker J, Beuvink I. Boos JA, et al. Nucleic Acids Res. 2013 Aug;41(15):e145. doi: 10.1093/nar/gkt515. Epub 2013 Jun 13. Nucleic Acids Res. 2013. PMID: 23766292 Free PMC article.
Characterization of nuclease-resistant ribozymes directed against hepatitis B virus RNA.
Morrissey DV, Lee PA, Johnson DA, Overly SL, McSwiggen JA, Beigelman L, Mokler VR, Maloney L, Vargeese C, Bowman K, O'Brien JT, Shaffer CS, Conrad A, Schmid P, Morrey JD, Macejak DG, Pavco PA, Blatt LM. Morrissey DV, et al. J Viral Hepat. 2002 Nov;9(6):411-8. doi: 10.1046/j.1365-2893.2002.00383.x. J Viral Hepat. 2002. PMID: 12431202
The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing.
Stalder L, Heusermann W, Sokol L, Trojer D, Wirz J, Hean J, Fritzsche A, Aeschimann F, Pfanzagl V, Basselet P, Weiler J, Hintersteiner M, Morrissey DV, Meisner-Kober NC. Stalder L, et al. Among authors: morrissey dv. EMBO J. 2013 Apr 17;32(8):1115-27. doi: 10.1038/emboj.2013.52. Epub 2013 Mar 19. EMBO J. 2013. PMID: 23511973 Free PMC article.
34 results