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Adaptive designs in clinical trials: why use them, and how to run and report them.
Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, Sydes MR, Villar SS, Wason JMS, Weir CJ, Wheeler GM, Yap C, Jaki T. Pallmann P, et al. BMC Med. 2018 Feb 28;16(1):29. doi: 10.1186/s12916-018-1017-7. BMC Med. 2018. PMID: 29490655 Free PMC article.
Procalcitonin Evaluation of Antibiotic Use in COVID-19 Hospitalised Patients (PEACH): Protocol for a Retrospective Observational Study.
Euden J, Pallmann P, Grozeva D, Albur M, Bond SE, Brookes-Howell L, Dark P, Hellyer T, Hopkins S, Howard P, Llewelyn MJ, Maboshe W, McCullagh IJ, Ogden M, Parsons H, Partridge D, Powell N, Shaw D, Shinkins B, Szakmany T, Todd S, Thomas-Jones E, West RM, Carrol ED, Sandoe JAT; PEACH Study Group. Euden J, et al. Among authors: pallmann p. Methods Protoc. 2022 Nov 28;5(6):95. doi: 10.3390/mps5060095. Methods Protoc. 2022. PMID: 36548137 Free PMC article.
Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design.
Dimairo M, Coates E, Pallmann P, Todd S, Julious SA, Jaki T, Wason J, Mander AP, Weir CJ, Koenig F, Walton MK, Biggs K, Nicholl J, Hamasaki T, Proschan MA, Scott JA, Ando Y, Hind D, Altman DG. Dimairo M, et al. Among authors: pallmann p. BMC Med. 2018 Nov 16;16(1):210. doi: 10.1186/s12916-018-1196-2. BMC Med. 2018. PMID: 30442137 Free PMC article.
The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design.
Dimairo M, Pallmann P, Wason J, Todd S, Jaki T, Julious SA, Mander AP, Weir CJ, Koenig F, Walton MK, Nicholl JP, Coates E, Biggs K, Hamasaki T, Proschan MA, Scott JA, Ando Y, Hind D, Altman DG; ACE Consensus Group. Dimairo M, et al. Among authors: pallmann p. Trials. 2020 Jun 17;21(1):528. doi: 10.1186/s13063-020-04334-x. Trials. 2020. PMID: 32546273 Free PMC article.
The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design.
Dimairo M, Pallmann P, Wason J, Todd S, Jaki T, Julious SA, Mander AP, Weir CJ, Koenig F, Walton MK, Nicholl JP, Coates E, Biggs K, Hamasaki T, Proschan MA, Scott JA, Ando Y, Hind D, Altman DG; ACE Consensus Group. Dimairo M, et al. Among authors: pallmann p. BMJ. 2020 Jun 17;369:m115. doi: 10.1136/bmj.m115. BMJ. 2020. PMID: 32554564 Free PMC article.
Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project.
Wilson N, Biggs K, Bowden S, Brown J, Dimairo M, Flight L, Hall J, Hockaday A, Jaki T, Lowe R, Murphy C, Pallmann P, Pilling MA, Snowdon C, Sydes MR, Villar SS, Weir CJ, Welburn J, Yap C, Maier R, Hancock H, Wason JMS. Wilson N, et al. Among authors: pallmann p. BMC Med. 2021 Oct 26;19(1):251. doi: 10.1186/s12916-021-02124-z. BMC Med. 2021. PMID: 34696781 Free PMC article.
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