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Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing.
Weng Y, Ishino T, Sievers A, Talukdar S, Chabot JR, Tam A, Duan W, Kerns K, Sousa E, He T, Logan A, Lee D, Li D, Zhou Y, Bernardo B, Joyce A, Kavosi M, O'Hara DM, Clark T, Guo J, Giragossian C, Stahl M, Calle RA, Kriz R, Somers W, Lin L. Weng Y, et al. Among authors: zhou y. Sci Rep. 2018 Mar 9;8(1):4241. doi: 10.1038/s41598-018-22456-w. Sci Rep. 2018. PMID: 29523796 Free PMC article.
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).
Huard K, Brown J, Jones JC, Cabral S, Futatsugi K, Gorgoglione M, Lanba A, Vera NB, Zhu Y, Yan Q, Zhou Y, Vernochet C, Riccardi K, Wolford A, Pirman D, Niosi M, Aspnes G, Herr M, Genung NE, Magee TV, Uccello DP, Loria P, Di L, Gosset JR, Hepworth D, Rolph T, Pfefferkorn JA, Erion DM. Huard K, et al. Among authors: zhou y. Sci Rep. 2015 Dec 1;5:17391. doi: 10.1038/srep17391. Sci Rep. 2015. PMID: 26620127 Free PMC article.
FGF21 Regulates Sweet and Alcohol Preference.
Talukdar S, Owen BM, Song P, Hernandez G, Zhang Y, Zhou Y, Scott WT, Paratala B, Turner T, Smith A, Bernardo B, Müller CP, Tang H, Mangelsdorf DJ, Goodwin B, Kliewer SA. Talukdar S, et al. Among authors: zhou y. Cell Metab. 2016 Feb 9;23(2):344-9. doi: 10.1016/j.cmet.2015.12.008. Epub 2015 Dec 24. Cell Metab. 2016. PMID: 26724861 Free PMC article.
A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.
Talukdar S, Zhou Y, Li D, Rossulek M, Dong J, Somayaji V, Weng Y, Clark R, Lanba A, Owen BM, Brenner MB, Trimmer JK, Gropp KE, Chabot JR, Erion DM, Rolph TP, Goodwin B, Calle RA. Talukdar S, et al. Among authors: zhou y. Cell Metab. 2016 Mar 8;23(3):427-40. doi: 10.1016/j.cmet.2016.02.001. Cell Metab. 2016. PMID: 26959184 Free article. Clinical Trial.
Loss of low-molecular-weight protein tyrosine phosphatase shows limited improvement in glucose tolerance but causes mild cardiac hypertrophy in mice.
Jensen-Cody S, Coyne ES, Ding X, Sebin A, Vogel J, Goldstein J, Rosahl TW, Zhou HH, Jacobs H, Champy MF, About GB, Talukdar S, Zhou Y. Jensen-Cody S, et al. Among authors: zhou y, zhou hh. Am J Physiol Endocrinol Metab. 2022 Jun 1;322(6):E517-E527. doi: 10.1152/ajpendo.00161.2021. Epub 2022 Apr 11. Am J Physiol Endocrinol Metab. 2022. PMID: 35403438 Free article.
Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity.
Cao J, Perez S, Goodwin B, Lin Q, Peng H, Qadri A, Zhou Y, Clark RW, Perreault M, Tobin JF, Gimeno RE. Cao J, et al. Among authors: zhou y. Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1176-87. doi: 10.1152/ajpendo.00666.2013. Epub 2014 Apr 8. Am J Physiol Endocrinol Metab. 2014. PMID: 24714397 Free article.
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