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A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S. Ladds MJGW, et al. Among authors: higgins m. Nat Commun. 2018 Mar 16;9(1):1107. doi: 10.1038/s41467-018-03441-3. Nat Commun. 2018. PMID: 29549331 Free PMC article.
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.
Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, Aoubala M, McCarthy A, Appleyard V, Murray KE, Baker L, Thompson A, Mathers J, Holland SJ, Stark MJ, Pass G, Woods J, Lane DP, Westwood NJ. Lain S, et al. Among authors: higgins m. Cancer Cell. 2008 May;13(5):454-63. doi: 10.1016/j.ccr.2008.03.004. Cancer Cell. 2008. PMID: 18455128 Free PMC article.
Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen.
Staples OD, Hollick JJ, Campbell J, Higgins M, McCarthy AR, Appleyard V, Murray KE, Baker L, Thompson A, Ronseaux S, Slawin AM, Lane DP, Westwood NJ, Lain S. Staples OD, et al. Among authors: higgins m. Cell Cycle. 2008 Nov 1;7(21):3417-27. doi: 10.4161/cc.7.21.6982. Epub 2008 Nov 15. Cell Cycle. 2008. PMID: 18971638 Free PMC article.
Mechanism-specific signatures for small-molecule p53 activators.
van Leeuwen IM, Higgins M, Campbell J, Brown CJ, McCarthy AR, Pirrie L, Westwood NJ, Laín S. van Leeuwen IM, et al. Among authors: higgins m. Cell Cycle. 2011 May 15;10(10):1590-8. doi: 10.4161/cc.10.10.15519. Epub 2011 May 15. Cell Cycle. 2011. PMID: 21490429
1,635 results