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Therapeutics discovery: From bench to first in-human trials.
Al-Hujaily EM, Khatlani T, Alehaideb Z, Ali R, Almuzaini B, Alrfaei BM, Iqbal J, Islam I, Malik S, Marwani BA, Massadeh S, Nehdi A, Alsomaie B, Debasi B, Bushnak I, Noibi S, Hussain S, Wajid WA, Armand JP, Gul S, Oyarzabal J, Rais R, Bountra C, Alaskar A, Knawy BA, Boudjelal M. Al-Hujaily EM, et al. Among authors: oyarzabal j. Biomed Rep. 2018 Mar;8(3):275-282. doi: 10.3892/br.2018.1052. Epub 2018 Jan 31. Biomed Rep. 2018. PMID: 29564125 Free PMC article.
Zebrafish: Speeding Up the Cancer Drug Discovery Process.
Letrado P, de Miguel I, Lamberto I, Díez-Martínez R, Oyarzabal J. Letrado P, et al. Among authors: oyarzabal j. Cancer Res. 2018 Nov 1;78(21):6048-6058. doi: 10.1158/0008-5472.CAN-18-1029. Epub 2018 Oct 16. Cancer Res. 2018. PMID: 30327381 Review.
Targeting the anion exchanger 2 with specific peptides as a new therapeutic approach in B lymphoid neoplasms.
Celay J, Lozano T, Concepcion AR, Beltrán E, Rudilla F, García-Barchino MJ, Robles EF, Rabal O, de Miguel I, Panizo C, Casares N, Oyarzabal J, Prieto J, Medina JF, Lasarte JJ, Martínez-Climent JÁ. Celay J, et al. Among authors: oyarzabal j. Haematologica. 2018 Jun;103(6):1065-1072. doi: 10.3324/haematol.2017.175687. Epub 2017 Nov 30. Haematologica. 2018. PMID: 29191842 Free PMC article.
Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.
Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, de Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella-Hermoso de Mendoza A, Sáez E, Espelosin M, Ursua S, Haizhong T, Wei W, Musheng X, Garcia-Osta A, Oyarzabal J. Rabal O, et al. Among authors: oyarzabal j. Eur J Med Chem. 2018 Apr 25;150:506-524. doi: 10.1016/j.ejmech.2018.03.005. Epub 2018 Mar 20. Eur J Med Chem. 2018. PMID: 29549837
Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma.
Rabal O, San José-Enériz E, Agirre X, Sánchez-Arias JA, de Miguel I, Ordoñez R, Garate L, Miranda E, Sáez E, Vilas-Zornoza A, Pineda-Lucena A, Estella A, Zhang F, Wu W, Xu M, Prosper F, Oyarzabal J. Rabal O, et al. Among authors: oyarzabal j. J Med Chem. 2021 Mar 25;64(6):3392-3426. doi: 10.1021/acs.jmedchem.0c02255. Epub 2021 Mar 4. J Med Chem. 2021. PMID: 33661013
Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents.
de Miguel I, Orbe J, Sánchez-Arias JA, Rodríguez JA, Salicio A, Rabal O, Belzunce M, Sáez E, Xu M, Wu W, Tan H, Ma H, Páramo JA, Oyarzabal J. de Miguel I, et al. Among authors: oyarzabal j. ACS Med Chem Lett. 2018 Apr 16;9(5):428-433. doi: 10.1021/acsmedchemlett.7b00549. eCollection 2018 May 10. ACS Med Chem Lett. 2018. PMID: 29795754 Free PMC article.
Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy.
Rabal O, San José-Enériz E, Agirre X, Sánchez-Arias JA, Vilas-Zornoza A, Ugarte A, de Miguel I, Miranda E, Garate L, Fraga M, Santamarina P, Fernandez Perez R, Ordoñez R, Sáez E, Roa S, García-Barchino MJ, Martínez-Climent JA, Liu Y, Wu W, Xu M, Prosper F, Oyarzabal J. Rabal O, et al. Among authors: oyarzabal j. J Med Chem. 2018 Aug 9;61(15):6518-6545. doi: 10.1021/acs.jmedchem.7b01926. Epub 2018 Jul 19. J Med Chem. 2018. PMID: 29953809
104 results