Simard ML - Search Results

1

Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

Matic S, Jiang M, Nicholls TJ, Uhler JP, Dirksen-Schwanenland C, Polosa PL, Simard ML, Li X, Atanassov I, Rackham O, Filipovska A, Stewart JB, Falkenberg M, Larsson NG, Milenkovic D. Matic S, et al. Among authors: simard ml. Nat Commun. 2018 Mar 23;9(1):1202. doi: 10.1038/s41467-018-03552-x. Nat Commun. 2018. PMID: 29572490 Free PMC article.

2

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

Kauppila JHK, Baines HL, Bratic A, Simard ML, Freyer C, Mourier A, Stamp C, Filograna R, Larsson NG, Greaves LC, Stewart JB. Kauppila JHK, et al. Among authors: simard ml. Cell Rep. 2016 Sep 13;16(11):2980-2990. doi: 10.1016/j.celrep.2016.08.037. Cell Rep. 2016. PMID: 27626666 Free PMC article.

3

A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.

Simard ML, Mourier A, Greaves LC, Taylor RW, Stewart JB. Simard ML, et al. J Pathol. 2018 Jul;245(3):311-323. doi: 10.1002/path.5084. Epub 2018 May 14. J Pathol. 2018. PMID: 29660116 Free PMC article.

4

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.

Gammage PA, Viscomi C, Simard ML, Costa ASH, Gaude E, Powell CA, Van Haute L, McCann BJ, Rebelo-Guiomar P, Cerutti R, Zhang L, Rebar EJ, Zeviani M, Frezza C, Stewart JB, Minczuk M. Gammage PA, et al. Among authors: simard ml. Nat Med. 2018 Nov;24(11):1691-1695. doi: 10.1038/s41591-018-0165-9. Epub 2018 Sep 24. Nat Med. 2018. PMID: 30250142 Free PMC article.

5

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse.

Filograna R, Koolmeister C, Upadhyay M, Pajak A, Clemente P, Wibom R, Simard ML, Wredenberg A, Freyer C, Stewart JB, Larsson NG. Filograna R, et al. Among authors: simard ml. Sci Adv. 2019 Apr 3;5(4):eaav9824. doi: 10.1126/sciadv.aav9824. eCollection 2019 Apr. Sci Adv. 2019. PMID: 30949583 Free PMC article.

6

Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction.

Milenkovic D, Sanz-Moreno A, Calzada-Wack J, Rathkolb B, Veronica Amarie O, Gerlini R, Aguilar-Pimentel A, Misic J, Simard ML, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Larsson NG. Milenkovic D, et al. Among authors: simard ml. PLoS Genet. 2022 May 9;18(5):e1010190. doi: 10.1371/journal.pgen.1010190. eCollection 2022 May. PLoS Genet. 2022. PMID: 35533204 Free PMC article.

7

Cell lineage-specific mitochondrial resilience during mammalian organogenesis.

Burr SP, Klimm F, Glynos A, Prater M, Sendon P, Nash P, Powell CA, Simard ML, Bonekamp NA, Charl J, Diaz H, Bozhilova LV, Nie Y, Zhang H, Frison M, Falkenberg M, Jones N, Minczuk M, Stewart JB, Chinnery PF. Burr SP, et al. Among authors: simard ml. Cell. 2023 Mar 16;186(6):1212-1229.e21. doi: 10.1016/j.cell.2023.01.034. Epub 2023 Feb 23. Cell. 2023. PMID: 36827974 Free article.

8

Noninvasive imaging of endogenous neural stem cell mobilization in vivo using positron emission tomography.

Rueger MA, Backes H, Walberer M, Neumaier B, Ullrich R, Simard ML, Emig B, Fink GR, Hoehn M, Graf R, Schroeter M. Rueger MA, et al. Among authors: simard ml. J Neurosci. 2010 May 5;30(18):6454-60. doi: 10.1523/JNEUROSCI.6092-09.2010. J Neurosci. 2010. PMID: 20445071 Free PMC article.

9

Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns.

Walberer M, Rueger MA, Simard ML, Emig B, Jander S, Fink GR, Schroeter M. Walberer M, et al. Among authors: simard ml. Exp Transl Stroke Med. 2010 Dec 20;2(1):22. doi: 10.1186/2040-7378-2-22. Exp Transl Stroke Med. 2010. PMID: 21171972 Free PMC article.

10

Natalizumab effects on immune cell responses in multiple sclerosis.

Niino M, Bodner C, Simard ML, Alatab S, Gano D, Kim HJ, Trigueiro M, Racicot D, Guérette C, Antel JP, Fournier A, Grand'Maison F, Bar-Or A. Niino M, et al. Among authors: simard ml. Ann Neurol. 2006 May;59(5):748-54. doi: 10.1002/ana.20859. Ann Neurol. 2006. PMID: 16634035 Clinical Trial.

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