Clarkson MW - Search Results

1

Rescue of conformational dynamics in enzyme catalysis by directed evolution.

Otten R, Liu L, Kenner LR, Clarkson MW, Mavor D, Tawfik DS, Kern D, Fraser JS. Otten R, et al. Among authors: clarkson mw. Nat Commun. 2018 Apr 3;9(1):1314. doi: 10.1038/s41467-018-03562-9. Nat Commun. 2018. PMID: 29615624 Free PMC article.

2

Hidden alternative structures of proline isomerase essential for catalysis.

Fraser JS, Clarkson MW, Degnan SC, Erion R, Kern D, Alber T. Fraser JS, et al. Among authors: clarkson mw. Nature. 2009 Dec 3;462(7273):669-73. doi: 10.1038/nature08615. Nature. 2009. PMID: 19956261 Free PMC article.

3

Free energy landscape of activation in a signalling protein at atomic resolution.

Pontiggia F, Pachov DV, Clarkson MW, Villali J, Hagan MF, Pande VS, Kern D. Pontiggia F, et al. Among authors: clarkson mw. Nat Commun. 2015 Jun 15;6:7284. doi: 10.1038/ncomms8284. Nat Commun. 2015. PMID: 26073309 Free PMC article.

4

Dissecting the microscopic steps of the cyclophilin A enzymatic cycle on the biological HIV-1 capsid substrate by NMR.

Bosco DA, Eisenmesser EZ, Clarkson MW, Wolf-Watz M, Labeikovsky W, Millet O, Kern D. Bosco DA, et al. Among authors: clarkson mw. J Mol Biol. 2010 Nov 12;403(5):723-38. doi: 10.1016/j.jmb.2010.08.001. Epub 2010 Aug 12. J Mol Biol. 2010. PMID: 20708627

5

Evidence against the "Y-T coupling" mechanism of activation in the response regulator NtrC.

Villali J, Pontiggia F, Clarkson MW, Hagan MF, Kern D. Villali J, et al. Among authors: clarkson mw. J Mol Biol. 2014 Apr 3;426(7):1554-67. doi: 10.1016/j.jmb.2013.12.027. Epub 2014 Jan 7. J Mol Biol. 2014. PMID: 24406745 Free PMC article.

6

Mesodynamics in the SARS nucleocapsid measured by NMR field cycling.

Clarkson MW, Lei M, Eisenmesser EZ, Labeikovsky W, Redfield A, Kern D. Clarkson MW, et al. J Biomol NMR. 2009 Sep;45(1-2):217-25. doi: 10.1007/s10858-009-9347-6. Epub 2009 Jul 30. J Biomol NMR. 2009. PMID: 19641854 Free PMC article.

7

Antiparallel EmrE exports drugs by exchanging between asymmetric structures.

Morrison EA, DeKoster GT, Dutta S, Vafabakhsh R, Clarkson MW, Bahl A, Kern D, Ha T, Henzler-Wildman KA. Morrison EA, et al. Among authors: clarkson mw. Nature. 2011 Dec 18;481(7379):45-50. doi: 10.1038/nature10703. Nature. 2011. PMID: 22178925 Free PMC article.

8

Transient non-native hydrogen bonds promote activation of a signaling protein.

Gardino AK, Villali J, Kivenson A, Lei M, Liu CF, Steindel P, Eisenmesser EZ, Labeikovsky W, Wolf-Watz M, Clarkson MW, Kern D. Gardino AK, et al. Among authors: clarkson mw. Cell. 2009 Dec 11;139(6):1109-18. doi: 10.1016/j.cell.2009.11.022. Cell. 2009. PMID: 20005804 Free PMC article.

9

Conserved conformational dynamics determine enzyme activity.

Torgeson KR, Clarkson MW, Granata D, Lindorff-Larsen K, Page R, Peti W. Torgeson KR, et al. Among authors: clarkson mw. Sci Adv. 2022 Aug 5;8(31):eabo5546. doi: 10.1126/sciadv.abo5546. Epub 2022 Aug 3. Sci Adv. 2022. PMID: 35921420 Free PMC article.

10

Cooperative dynamics across distinct structural elements regulate PTP1B activity.

Torgeson KR, Clarkson MW, Kumar GS, Page R, Peti W. Torgeson KR, et al. Among authors: clarkson mw. J Biol Chem. 2020 Oct 2;295(40):13829-13837. doi: 10.1074/jbc.RA120.014652. Epub 2020 Jul 31. J Biol Chem. 2020. PMID: 32737198 Free PMC article.

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