Fraser JS - Search Results

1

Rescue of conformational dynamics in enzyme catalysis by directed evolution.

Otten R, Liu L, Kenner LR, Clarkson MW, Mavor D, Tawfik DS, Kern D, Fraser JS. Otten R, et al. Among authors: fraser js. Nat Commun. 2018 Apr 3;9(1):1314. doi: 10.1038/s41467-018-03562-9. Nat Commun. 2018. PMID: 29615624 Free PMC article.

2

Hidden alternative structures of proline isomerase essential for catalysis.

Fraser JS, Clarkson MW, Degnan SC, Erion R, Kern D, Alber T. Fraser JS, et al. Nature. 2009 Dec 3;462(7273):669-73. doi: 10.1038/nature08615. Nature. 2009. PMID: 19956261 Free PMC article.

3

Systematic functional prioritization of protein posttranslational modifications.

Beltrao P, Albanèse V, Kenner LR, Swaney DL, Burlingame A, Villén J, Lim WA, Fraser JS, Frydman J, Krogan NJ. Beltrao P, et al. Among authors: fraser js. Cell. 2012 Jul 20;150(2):413-25. doi: 10.1016/j.cell.2012.05.036. Cell. 2012. PMID: 22817900 Free PMC article.

4

Automated identification of functional dynamic contact networks from X-ray crystallography.

van den Bedem H, Bhabha G, Yang K, Wright PE, Fraser JS. van den Bedem H, et al. Among authors: fraser js. Nat Methods. 2013 Sep;10(9):896-902. doi: 10.1038/nmeth.2592. Epub 2013 Aug 4. Nat Methods. 2013. PMID: 23913260 Free PMC article.

5

Keep on moving: discovering and perturbing the conformational dynamics of enzymes.

Bhabha G, Biel JT, Fraser JS. Bhabha G, et al. Among authors: fraser js. Acc Chem Res. 2015 Feb 17;48(2):423-30. doi: 10.1021/ar5003158. Epub 2014 Dec 24. Acc Chem Res. 2015. PMID: 25539415 Free PMC article. Review.

6

Integrative, dynamic structural biology at atomic resolution--it's about time.

van den Bedem H, Fraser JS. van den Bedem H, et al. Among authors: fraser js. Nat Methods. 2015 Apr;12(4):307-18. doi: 10.1038/nmeth.3324. Nat Methods. 2015. PMID: 25825836 Free PMC article. Review.

7

Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.

Dellus-Gur E, Elias M, Caselli E, Prati F, Salverda ML, de Visser JA, Fraser JS, Tawfik DS. Dellus-Gur E, et al. Among authors: fraser js. J Mol Biol. 2015 Jul 17;427(14):2396-409. doi: 10.1016/j.jmb.2015.05.011. Epub 2015 May 22. J Mol Biol. 2015. PMID: 26004540 Free PMC article.

8

EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy.

Barad BA, Echols N, Wang RY, Cheng Y, DiMaio F, Adams PD, Fraser JS. Barad BA, et al. Among authors: fraser js. Nat Methods. 2015 Oct;12(10):943-6. doi: 10.1038/nmeth.3541. Epub 2015 Aug 17. Nat Methods. 2015. PMID: 26280328 Free PMC article.

9

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.

Keedy DA, Kenner LR, Warkentin M, Woldeyes RA, Hopkins JB, Thompson MC, Brewster AS, Van Benschoten AH, Baxter EL, Uervirojnangkoorn M, McPhillips SE, Song J, Alonso-Mori R, Holton JM, Weis WI, Brunger AT, Soltis SM, Lemke H, Gonzalez A, Sauter NK, Cohen AE, van den Bedem H, Thorne RE, Fraser JS. Keedy DA, et al. Among authors: fraser js. Elife. 2015 Sep 30;4:e07574. doi: 10.7554/eLife.07574. Elife. 2015. PMID: 26422513 Free PMC article.

10

Measuring and modeling diffuse scattering in protein X-ray crystallography.

Van Benschoten AH, Liu L, Gonzalez A, Brewster AS, Sauter NK, Fraser JS, Wall ME. Van Benschoten AH, et al. Among authors: fraser js. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4069-74. doi: 10.1073/pnas.1524048113. Epub 2016 Mar 28. Proc Natl Acad Sci U S A. 2016. PMID: 27035972 Free PMC article.

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