Tawfik DS - Search Results

1

Rescue of conformational dynamics in enzyme catalysis by directed evolution.

Otten R, Liu L, Kenner LR, Clarkson MW, Mavor D, Tawfik DS, Kern D, Fraser JS. Otten R, et al. Among authors: tawfik ds. Nat Commun. 2018 Apr 3;9(1):1314. doi: 10.1038/s41467-018-03562-9. Nat Commun. 2018. PMID: 29615624 Free PMC article.

2

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.

Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. Harel M, et al. Among authors: tawfik ds. Nat Struct Mol Biol. 2004 May;11(5):412-9. doi: 10.1038/nsmb767. Epub 2004 Apr 18. Nat Struct Mol Biol. 2004. PMID: 15098021

3

Evolution of new protein topologies through multistep gene rearrangements.

Peisajovich SG, Rockah L, Tawfik DS. Peisajovich SG, et al. Among authors: tawfik ds. Nat Genet. 2006 Feb;38(2):168-74. doi: 10.1038/ng1717. Epub 2006 Jan 15. Nat Genet. 2006. PMID: 16415885

4

Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein.

Bershtein S, Segal M, Bekerman R, Tokuriki N, Tawfik DS. Bershtein S, et al. Among authors: tawfik ds. Nature. 2006 Dec 14;444(7121):929-32. doi: 10.1038/nature05385. Epub 2006 Nov 19. Nature. 2006. PMID: 17122770

5

Protein engineers turned evolutionists.

Peisajovich SG, Tawfik DS. Peisajovich SG, et al. Among authors: tawfik ds. Nat Methods. 2007 Dec;4(12):991-4. doi: 10.1038/nmeth1207-991. Nat Methods. 2007. PMID: 18049465 Review.

6

Advances in laboratory evolution of enzymes.

Bershtein S, Tawfik DS. Bershtein S, et al. Among authors: tawfik ds. Curr Opin Chem Biol. 2008 Apr;12(2):151-8. doi: 10.1016/j.cbpa.2008.01.027. Epub 2008 Mar 7. Curr Opin Chem Biol. 2008. PMID: 18284924 Review.

7

Kemp elimination catalysts by computational enzyme design.

Röthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D. Röthlisberger D, et al. Among authors: tawfik ds. Nature. 2008 May 8;453(7192):190-5. doi: 10.1038/nature06879. Epub 2008 Mar 19. Nature. 2008. PMID: 18354394

8

Directed enzyme evolution via small and effective neutral drift libraries.

Gupta RD, Tawfik DS. Gupta RD, et al. Among authors: tawfik ds. Nat Methods. 2008 Nov;5(11):939-42. doi: 10.1038/nmeth.1262. Epub 2008 Oct 19. Nat Methods. 2008. PMID: 18931667

9

Chaperonin overexpression promotes genetic variation and enzyme evolution.

Tokuriki N, Tawfik DS. Tokuriki N, et al. Among authors: tawfik ds. Nature. 2009 Jun 4;459(7247):668-73. doi: 10.1038/nature08009. Nature. 2009. PMID: 19494908

10

Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.

Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R, Silman I, Sussman JL, Tawfik DS. Gupta RD, et al. Among authors: tawfik ds. Nat Chem Biol. 2011 Feb;7(2):120-5. doi: 10.1038/nchembio.510. Epub 2011 Jan 9. Nat Chem Biol. 2011. PMID: 21217689

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