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CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.
Antony PA, Piccirillo CA, Akpinarli A, Finkelstein SE, Speiss PJ, Surman DR, Palmer DC, Chan CC, Klebanoff CA, Overwijk WW, Rosenberg SA, Restifo NP. Antony PA, et al. Among authors: overwijk ww. J Immunol. 2005 Mar 1;174(5):2591-601. doi: 10.4049/jimmunol.174.5.2591. J Immunol. 2005. PMID: 15728465 Free PMC article.
Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant.
Overwijk WW, de Visser KE, Tirion FH, de Jong LA, Pols TW, van der Velden YU, van den Boorn JG, Keller AM, Buurman WA, Theoret MR, Blom B, Restifo NP, Kruisbeek AM, Kastelein RA, Haanen JB. Overwijk WW, et al. J Immunol. 2006 May 1;176(9):5213-22. doi: 10.4049/jimmunol.176.9.5213. J Immunol. 2006. PMID: 16621986 Free PMC article.
T helper 17 cells promote cytotoxic T cell activation in tumor immunity.
Martin-Orozco N, Muranski P, Chung Y, Yang XO, Yamazaki T, Lu S, Hwu P, Restifo NP, Overwijk WW, Dong C. Martin-Orozco N, et al. Among authors: overwijk ww. Immunity. 2009 Nov 20;31(5):787-98. doi: 10.1016/j.immuni.2009.09.014. Epub 2009 Oct 29. Immunity. 2009. PMID: 19879162 Free PMC article.
116 results