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L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis.
Schauer SN, Carreira PE, Shukla R, Gerhardt DJ, Gerdes P, Sanchez-Luque FJ, Nicoli P, Kindlova M, Ghisletti S, Santos AD, Rapoud D, Samuel D, Faivre J, Ewing AD, Richardson SR, Faulkner GJ. Schauer SN, et al. Among authors: shukla r. Genome Res. 2018 May;28(5):639-653. doi: 10.1101/gr.226993.117. Epub 2018 Apr 11. Genome Res. 2018. PMID: 29643204 Free PMC article.
Extensive somatic L1 retrotransposition in colorectal tumors.
Solyom S, Ewing AD, Rahrmann EP, Doucet T, Nelson HH, Burns MB, Harris RS, Sigmon DF, Casella A, Erlanger B, Wheelan S, Upton KR, Shukla R, Faulkner GJ, Largaespada DA, Kazazian HH Jr. Solyom S, et al. Among authors: shukla r. Genome Res. 2012 Dec;22(12):2328-38. doi: 10.1101/gr.145235.112. Epub 2012 Sep 11. Genome Res. 2012. PMID: 22968929 Free PMC article.
Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma.
Shukla R, Upton KR, Muñoz-Lopez M, Gerhardt DJ, Fisher ME, Nguyen T, Brennan PM, Baillie JK, Collino A, Ghisletti S, Sinha S, Iannelli F, Radaelli E, Dos Santos A, Rapoud D, Guettier C, Samuel D, Natoli G, Carninci P, Ciccarelli FD, Garcia-Perez JL, Faivre J, Faulkner GJ. Shukla R, et al. Cell. 2013 Mar 28;153(1):101-11. doi: 10.1016/j.cell.2013.02.032. Cell. 2013. PMID: 23540693 Free PMC article.
Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Cañadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG. Klawitter S, et al. Among authors: shukla r. Nat Commun. 2016 Jan 8;7:10286. doi: 10.1038/ncomms10286. Nat Commun. 2016. PMID: 26743714 Free PMC article.
Mutual epithelium-macrophage dependency in liver carcinogenesis mediated by ST18.
Ravà M, D'Andrea A, Doni M, Kress TR, Ostuni R, Bianchi V, Morelli MJ, Collino A, Ghisletti S, Nicoli P, Recordati C, Iascone M, Sonzogni A, D'Antiga L, Shukla R, Faulkner GJ, Natoli G, Campaner S, Amati B. Ravà M, et al. Among authors: shukla r. Hepatology. 2017 May;65(5):1708-1719. doi: 10.1002/hep.28942. Epub 2016 Dec 30. Hepatology. 2017. PMID: 27859418 Free PMC article.
Author Correction: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.
Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Cañadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG. Klawitter S, et al. Among authors: shukla r. Nat Commun. 2018 Dec 19;9(1):5398. doi: 10.1038/s41467-018-07917-0. Nat Commun. 2018. PMID: 30568248 Free PMC article.
HCV Activates Somatic L1 Retrotransposition-A Potential Hepatocarcinogenesis Pathway.
Sudhindar PD, Wainwright D, Saha S, Howarth R, McCain M, Bury Y, Saha SS, McPherson S, Reeves H, Patel AH, Faulkner GJ, Lunec J, Shukla R. Sudhindar PD, et al. Among authors: shukla r. Cancers (Basel). 2021 Oct 11;13(20):5079. doi: 10.3390/cancers13205079. Cancers (Basel). 2021. PMID: 34680227 Free PMC article.
Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation.
Zadran B, Sudhindar PD, Wainwright D, Bury Y, Luli S, Howarth R, McCain MV, Watson R, Huet H, Palinkas F, Berlinguer-Palmini R, Casement J, Mann DA, Oakley F, Lunec J, Reeves H, Faulkner GJ, Shukla R. Zadran B, et al. Among authors: shukla r. Br J Cancer. 2023 Mar;128(7):1236-1248. doi: 10.1038/s41416-023-02154-9. Epub 2023 Jan 27. Br J Cancer. 2023. PMID: 36707636 Free PMC article.
Key features of the environment promoting liver cancer in the absence of cirrhosis.
Zaki MYW, Mahdi AK, Patman GL, Whitehead A, Maurício JP, McCain MV, Televantou D, Abou-Beih S, Ramon-Gil E, Watson R, Cox C, Leslie J, Wilson C, Govaere O, Lunec J, Mann DA, Nakjang S, Oakley F, Shukla R, Anstee QM, Tiniakos D, Reeves HL. Zaki MYW, et al. Among authors: shukla r. Sci Rep. 2021 Aug 18;11(1):16727. doi: 10.1038/s41598-021-96076-2. Sci Rep. 2021. PMID: 34408183 Free PMC article.
1,929 results