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Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin.
Abdulmalik O, Ghatge MS, Musayev FN, Parikh A, Chen Q, Yang J, Nnamani I, Danso-Danquah R, Eseonu DN, Asakura T, Abraham DJ, Venitz J, Safo MK. Abdulmalik O, et al. Among authors: chen q. Acta Crystallogr D Biol Crystallogr. 2011 Nov;67(Pt 11):920-8. doi: 10.1107/S0907444911036353. Epub 2011 Oct 19. Acta Crystallogr D Biol Crystallogr. 2011. PMID: 22101818 Free PMC article.
Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.
Xu GG, Pagare PP, Ghatge MS, Safo RP, Gazi A, Chen Q, David T, Alabbas AB, Musayev FN, Venitz J, Zhang Y, Safo MK, Abdulmalik O. Xu GG, et al. Among authors: chen q. Mol Pharm. 2017 Oct 2;14(10):3499-3511. doi: 10.1021/acs.molpharmaceut.7b00553. Epub 2017 Sep 13. Mol Pharm. 2017. PMID: 28858508 Free PMC article.
A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.
Nakagawa A, Ferrari M, Schleifer G, Cooper MK, Liu C, Yu B, Berra L, Klings ES, Safo RS, Chen Q, Musayev FN, Safo MK, Abdulmalik O, Bloch DB, Zapol WM. Nakagawa A, et al. Among authors: chen q. Mol Pharm. 2018 May 7;15(5):1954-1963. doi: 10.1021/acs.molpharmaceut.8b00108. Epub 2018 Apr 18. Mol Pharm. 2018. PMID: 29634905 Free PMC article.
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