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Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KMA, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M. Natunen T, et al. Among authors: leskela s. Neurobiol Dis. 2016 Jan;85:187-205. doi: 10.1016/j.nbd.2015.11.005. Epub 2015 Nov 10. Neurobiol Dis. 2016. PMID: 26563932
Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells.
Leskelä S, Huber N, Hoffmann D, Rostalski H, Remes AM, Takalo M, Hiltunen M, Haapasalo A. Leskelä S, et al. Biochim Biophys Acta Mol Cell Res. 2021 Jun;1868(7):119021. doi: 10.1016/j.bbamcr.2021.119021. Epub 2021 Mar 26. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 33775797 Free article.
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.
Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. Martiskainen H, et al. Among authors: leskela s. J Neuroinflammation. 2017 Nov 7;14(1):215. doi: 10.1186/s12974-017-0991-6. J Neuroinflammation. 2017. PMID: 29115990 Free PMC article.
BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci.
Rostalski H, Hietanen T, Leskelä S, Behánová A, Abdollahzadeh A, Wittrahm R, Mäkinen P, Huber N, Hoffmann D, Solje E, Remes AM, Natunen T, Takalo M, Tohka J, Hiltunen M, Haapasalo A. Rostalski H, et al. Among authors: leskela s. Front Neurol. 2020 Oct 6;11:550140. doi: 10.3389/fneur.2020.550140. eCollection 2020. Front Neurol. 2020. PMID: 33123074 Free PMC article.
55 results