Brennan A - Search Results

1

Proteomic analysis of serum and sputum analytes distinguishes controlled and poorly controlled asthmatics.

Kasaian MT, Lee J, Brennan A, Danto SI, Black KE, Fitz L, Dixon AE. Kasaian MT, et al. Among authors: brennan a. Clin Exp Allergy. 2018 Jul;48(7):814-824. doi: 10.1111/cea.13151. Epub 2018 May 15. Clin Exp Allergy. 2018. PMID: 29665127

2

Therapeutic activity of an interleukin-4/interleukin-13 dual antagonist on oxazolone-induced colitis in mice.

Kasaian MT, Page KM, Fish S, Brennan A, Cook TA, Moreira K, Zhang M, Jesson M, Marquette K, Agostinelli R, Lee J, Williams CM, Tchistiakova L, Thakker P. Kasaian MT, et al. Among authors: brennan a. Immunology. 2014 Nov;143(3):416-27. doi: 10.1111/imm.12319. Immunology. 2014. PMID: 24831554 Free PMC article.

3

An IL-4/IL-13 dual antagonist reduces lung inflammation, airway hyperresponsiveness, and IgE production in mice.

Kasaian MT, Marquette K, Fish S, DeClercq C, Agostinelli R, Cook TA, Brennan A, Lee J, Fitz L, Brooks J, Vugmeyster Y, Williams CM, Lofquist A, Tchistiakova L. Kasaian MT, et al. Among authors: brennan a. Am J Respir Cell Mol Biol. 2013 Jul;49(1):37-46. doi: 10.1165/rcmb.2012-0500OC. Am J Respir Cell Mol Biol. 2013. PMID: 23449738

4

Modulation of the IL-33/IL-13 Axis in Obesity by IL-13Rα2.

Duffen J, Zhang M, Masek-Hammerman K, Nunez A, Brennan A, Jones JEC, Morin J, Nocka K, Kasaian M. Duffen J, et al. Among authors: brennan a. J Immunol. 2018 Feb 15;200(4):1347-1359. doi: 10.4049/jimmunol.1701256. Epub 2018 Jan 5. J Immunol. 2018. PMID: 29305434

5

Activation-induced cellular accumulation of histamine in immature but not mature murine mast cells.

Fitz LJ, Brennan A, Wood CR, Goldman SJ, Kasaian MT. Fitz LJ, et al. Among authors: brennan a. Cell Mol Life Sci. 2008 May;65(10):1585-95. doi: 10.1007/s00018-008-8106-2. Cell Mol Life Sci. 2008. PMID: 18408884 Free PMC article.

6

Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases.

Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT. Margulis A, et al. Among authors: brennan am. J Immunol. 2009 Aug 1;183(3):1739-50. doi: 10.4049/jimmunol.0803951. Epub 2009 Jul 10. J Immunol. 2009. PMID: 19592653

7

Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.

Cole DC, Asselin M, Brennan A, Czerwinski R, Ellingboe JW, Fitz L, Greco R, Huang X, Joseph-McCarthy D, Kelly MF, Kirisits M, Lee J, Li Y, Morgan P, Stock JR, Tsao DH, Wissner A, Yang X, Chaudhary D. Cole DC, et al. Among authors: brennan a. J Med Chem. 2008 Oct 9;51(19):5958-63. doi: 10.1021/jm800214a. Epub 2008 Sep 11. J Med Chem. 2008. PMID: 18783200

8

C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCtheta inhibitors: Part I.

Subrath J, Wang D, Wu B, Niu C, Boschelli DH, Lee J, Yang X, Brennan A, Chaudhary D. Subrath J, et al. Among authors: brennan a. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5423-5. doi: 10.1016/j.bmcl.2009.07.109. Epub 2009 Jul 26. Bioorg Med Chem Lett. 2009. PMID: 19682896

9

Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.

Casimiro-Garcia A, Allais C, Brennan A, Choi C, Dower G, Farley KA, Fleming M, Flick A, Frisbie RK, Hall J, Hepworth D, Jones H, Knafels JD, Kortum S, Lovering FE, Mathias JP, Mohan S, Morgan PM, Parng C, Parris K, Pullen N, Schlerman F, Stansfield J, Strohbach JW, Vajdos FF, Vincent F, Wang H, Wang X, Webster R, Wright SW. Casimiro-Garcia A, et al. Among authors: brennan a. J Med Chem. 2022 Jan 13;65(1):757-784. doi: 10.1021/acs.jmedchem.1c01849. Epub 2021 Dec 30. J Med Chem. 2022. PMID: 34967602

10

5-Vinyl-3-pyridinecarbonitrile inhibitors of PKCtheta: optimization of enzymatic and functional activity.

Tumey LN, Bhagirath N, Brennan A, Brooijmans N, Lee J, Yang X, Boschelli DH. Tumey LN, et al. Among authors: brennan a. Bioorg Med Chem. 2009 Dec 1;17(23):7933-48. doi: 10.1016/j.bmc.2009.10.020. Epub 2009 Oct 31. Bioorg Med Chem. 2009. PMID: 19884013

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