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Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.
Esquejo RM, Salatto CT, Delmore J, Albuquerque B, Reyes A, Shi Y, Moccia R, Cokorinos E, Peloquin M, Monetti M, Barricklow J, Bollinger E, Smith BK, Day EA, Nguyen C, Geoghegan KF, Kreeger JM, Opsahl A, Ward J, Kalgutkar AS, Tess D, Butler L, Shirai N, Osborne TF, Steinberg GR, Birnbaum MJ, Cameron KO, Miller RA. Esquejo RM, et al. Among authors: osborne tf. EBioMedicine. 2018 May;31:122-132. doi: 10.1016/j.ebiom.2018.04.009. Epub 2018 Apr 8. EBioMedicine. 2018. PMID: 29673898 Free PMC article.
SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation.
Roqueta-Rivera M, Esquejo RM, Phelan PE, Sandor K, Daniel B, Foufelle F, Ding J, Li X, Khorasanizadeh S, Osborne TF. Roqueta-Rivera M, et al. Among authors: osborne tf. Cell Metab. 2016 Sep 13;24(3):474-484. doi: 10.1016/j.cmet.2016.07.025. Epub 2016 Aug 25. Cell Metab. 2016. PMID: 27568546 Free PMC article.
miRNA and cholesterol homeostasis.
Jeon TI, Osborne TF. Jeon TI, et al. Among authors: osborne tf. Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2041-2046. doi: 10.1016/j.bbalip.2016.01.005. Epub 2016 Jan 15. Biochim Biophys Acta. 2016. PMID: 26778752 Free PMC article. Review.
Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis.
Key CC, Liu M, Kurtz CL, Chung S, Boudyguina E, Dinh TA, Bashore A, Phelan PE, Freedman BI, Osborne TF, Zhu X, Ma L, Sethupathy P, Biddinger SB, Parks JS. Key CC, et al. Among authors: osborne tf. Cell Rep. 2017 Jun 6;19(10):2116-2129. doi: 10.1016/j.celrep.2017.05.032. Cell Rep. 2017. PMID: 28591582 Free PMC article.
182 results