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Page 1
Immunotherapy with Aducanumab Restores Calcium Homeostasis in Tg2576 Mice.
Kastanenka KV, Bussiere T, Shakerdge N, Qian F, Weinreb PH, Rhodes K, Bacskai BJ. Kastanenka KV, et al. Among authors: weinreb ph. J Neurosci. 2016 Dec 14;36(50):12549-12558. doi: 10.1523/JNEUROSCI.2080-16.2016. Epub 2016 Nov 3. J Neurosci. 2016. PMID: 27810931 Free PMC article.
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies.
Linse S, Scheidt T, Bernfur K, Vendruscolo M, Dobson CM, Cohen SIA, Sileikis E, Lundqvist M, Qian F, O'Malley T, Bussiere T, Weinreb PH, Xu CK, Meisl G, Devenish SRA, Knowles TPJ, Hansson O. Linse S, et al. Among authors: weinreb ph. Nat Struct Mol Biol. 2020 Dec;27(12):1125-1133. doi: 10.1038/s41594-020-0505-6. Epub 2020 Sep 28. Nat Struct Mol Biol. 2020. PMID: 32989305
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Weihofen A, Liu Y, Arndt JW, Huy C, Quan C, Smith BA, Baeriswyl JL, Cavegn N, Senn L, Su L, Marsh G, Auluck PK, Montrasio F, Nitsch RM, Hirst WD, Cedarbaum JM, Pepinsky RB, Grimm J, Weinreb PH. Weihofen A, et al. Among authors: weinreb ph. Neurobiol Dis. 2019 Apr;124:276-288. doi: 10.1016/j.nbd.2018.10.016. Epub 2018 Oct 28. Neurobiol Dis. 2019. PMID: 30381260 Free article.
The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.
Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A. Sevigny J, et al. Among authors: weinreb ph. Nature. 2016 Sep 1;537(7618):50-6. doi: 10.1038/nature19323. Nature. 2016. Update in: Nature. 2017 Jun 21;546(7659):564. doi: 10.1038/nature22809 PMID: 27582220 Updated.
Characterization of tau binding by gosuranemab.
Sopko R, Golonzhka O, Arndt J, Quan C, Czerkowicz J, Cameron A, Smith B, Murugesan Y, Gibbons G, Kim SJ, Trojanowski JQ, Lee VMY, Brunden KR, Graham DL, Weinreb PH, Hering H. Sopko R, et al. Among authors: weinreb ph. Neurobiol Dis. 2020 Dec;146:105120. doi: 10.1016/j.nbd.2020.105120. Epub 2020 Sep 28. Neurobiol Dis. 2020. PMID: 32991997 Free article.
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life.
Uhlmann RE, Rother C, Rasmussen J, Schelle J, Bergmann C, Ullrich Gavilanes EM, Fritschi SK, Buehler A, Baumann F, Skodras A, Al-Shaana R, Beschorner N, Ye L, Kaeser SA, Obermüller U, Christensen S, Kartberg F, Stavenhagen JB, Rahfeld JU, Cynis H, Qian F, Weinreb PH, Bussiere T, Walker LC, Staufenbiel M, Jucker M. Uhlmann RE, et al. Among authors: weinreb ph. Nat Neurosci. 2020 Dec;23(12):1580-1588. doi: 10.1038/s41593-020-00737-w. Epub 2020 Nov 16. Nat Neurosci. 2020. PMID: 33199898 Free PMC article.
Characterization of trisulfide modification in antibodies.
Gu S, Wen D, Weinreb PH, Sun Y, Zhang L, Foley SF, Kshirsagar R, Evans D, Mi S, Meier W, Pepinsky RB. Gu S, et al. Among authors: weinreb ph. Anal Biochem. 2010 May 1;400(1):89-98. doi: 10.1016/j.ab.2010.01.019. Epub 2010 Jan 18. Anal Biochem. 2010. PMID: 20085742
78 results