Tokuriki N - Search Results

1

Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein.

Clifton BE, Kaczmarski JA, Carr PD, Gerth ML, Tokuriki N, Jackson CJ. Clifton BE, et al. Among authors: tokuriki n. Nat Chem Biol. 2018 Jun;14(6):542-547. doi: 10.1038/s41589-018-0043-2. Epub 2018 Apr 23. Nat Chem Biol. 2018. PMID: 29686357

2

Chaperonin overexpression promotes genetic variation and enzyme evolution.

Tokuriki N, Tawfik DS. Tokuriki N, et al. Nature. 2009 Jun 4;459(7247):668-73. doi: 10.1038/nature08009. Nature. 2009. PMID: 19494908

3

Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase.

Jackson CJ, Foo JL, Tokuriki N, Afriat L, Carr PD, Kim HK, Schenk G, Tawfik DS, Ollis DL. Jackson CJ, et al. Among authors: tokuriki n. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21631-6. doi: 10.1073/pnas.0907548106. Epub 2009 Dec 4. Proc Natl Acad Sci U S A. 2009. PMID: 19966226 Free PMC article.

4

Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme.

Tokuriki N, Jackson CJ, Afriat-Jurnou L, Wyganowski KT, Tang R, Tawfik DS. Tokuriki N, et al. Nat Commun. 2012;3:1257. doi: 10.1038/ncomms2246. Nat Commun. 2012. PMID: 23212386 Free article.

5

Modulating protein stability - directed evolution strategies for improved protein function.

Socha RD, Tokuriki N. Socha RD, et al. Among authors: tokuriki n. FEBS J. 2013 Nov;280(22):5582-95. doi: 10.1111/febs.12354. Epub 2013 Jun 18. FEBS J. 2013. PMID: 23711026 Free article. Review.

6

GroEL/ES buffering and compensatory mutations promote protein evolution by stabilizing folding intermediates.

Wyganowski KT, Kaltenbach M, Tokuriki N. Wyganowski KT, et al. Among authors: tokuriki n. J Mol Biol. 2013 Sep 23;425(18):3403-14. doi: 10.1016/j.jmb.2013.06.028. Epub 2013 Jun 28. J Mol Biol. 2013. PMID: 23810906

7

Dynamics and constraints of enzyme evolution.

Kaltenbach M, Tokuriki N. Kaltenbach M, et al. Among authors: tokuriki n. J Exp Zool B Mol Dev Evol. 2014 Nov;322(7):468-87. doi: 10.1002/jez.b.22562. Epub 2014 Feb 13. J Exp Zool B Mol Dev Evol. 2014. PMID: 24522979 Review.

8

Connectivity between catalytic landscapes of the metallo-β-lactamase superfamily.

Baier F, Tokuriki N. Baier F, et al. Among authors: tokuriki n. J Mol Biol. 2014 Jun 26;426(13):2442-56. doi: 10.1016/j.jmb.2014.04.013. Epub 2014 Apr 24. J Mol Biol. 2014. PMID: 24769192

9

Enzyme dynamics and engineering: one step at a time.

Tokuriki N, Jackson CJ. Tokuriki N, et al. Chem Biol. 2014 Oct 23;21(10):1259-1260. doi: 10.1016/j.chembiol.2014.10.003. Chem Biol. 2014. PMID: 25373342

10

Reverse evolution leads to genotypic incompatibility despite functional and active site convergence.

Kaltenbach M, Jackson CJ, Campbell EC, Hollfelder F, Tokuriki N. Kaltenbach M, et al. Among authors: tokuriki n. Elife. 2015 Aug 14;4:e06492. doi: 10.7554/eLife.06492. Elife. 2015. PMID: 26274563 Free PMC article.

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