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Emergence of High-Level Colistin Resistance in an Acinetobacter baumannii Clinical Isolate Mediated by Inactivation of the Global Regulator H-NS.
Deveson Lucas D, Crane B, Wright A, Han ML, Moffatt J, Bulach D, Gladman SL, Powell D, Aranda J, Seemann T, Machado D, Pacheco T, Marques T, Viveiros M, Nation R, Li J, Harper M, Boyce JD. Deveson Lucas D, et al. Among authors: moffatt j. Antimicrob Agents Chemother. 2018 Jun 26;62(7):e02442-17. doi: 10.1128/AAC.02442-17. Print 2018 Jul. Antimicrob Agents Chemother. 2018. PMID: 29712662 Free PMC article.
Different surface charge of colistin-susceptible and -resistant Acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment.
Soon RL, Nation RL, Cockram S, Moffatt JH, Harper M, Adler B, Boyce JD, Larson I, Li J. Soon RL, et al. Among authors: moffatt jh. J Antimicrob Chemother. 2011 Jan;66(1):126-33. doi: 10.1093/jac/dkq422. Epub 2010 Nov 16. J Antimicrob Chemother. 2011. PMID: 21081544 Free PMC article.
Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosamine.
Henry R, Vithanage N, Harrison P, Seemann T, Coutts S, Moffatt JH, Nation RL, Li J, Harper M, Adler B, Boyce JD. Henry R, et al. Among authors: moffatt jh. Antimicrob Agents Chemother. 2012 Jan;56(1):59-69. doi: 10.1128/AAC.05191-11. Epub 2011 Oct 24. Antimicrob Agents Chemother. 2012. PMID: 22024825 Free PMC article.
Lipopolysaccharide-deficient Acinetobacter baumannii shows altered signaling through host Toll-like receptors and increased susceptibility to the host antimicrobial peptide LL-37.
Moffatt JH, Harper M, Mansell A, Crane B, Fitzsimons TC, Nation RL, Li J, Adler B, Boyce JD. Moffatt JH, et al. Infect Immun. 2013 Mar;81(3):684-9. doi: 10.1128/IAI.01362-12. Epub 2012 Dec 17. Infect Immun. 2013. PMID: 23250952 Free PMC article.
We have shown previously that A. baumannii can become resistant to the last-line antibiotic colistin via the loss of lipopolysaccharide (LPS), including the lipid A anchor, from the outer membrane (J. H. Moffatt, M. Harper, P. Harrison, J. D. Hale, E. Vinogra …
We have shown previously that A. baumannii can become resistant to the last-line antibiotic colistin via the loss of lipopolysaccharide (LPS …
Mechanisms of Polymyxin Resistance.
Moffatt JH, Harper M, Boyce JD. Moffatt JH, et al. Adv Exp Med Biol. 2019;1145:55-71. doi: 10.1007/978-3-030-16373-0_5. Adv Exp Med Biol. 2019. PMID: 31364071 Review.
Coxiella burnetii: turning hostility into a home.
Moffatt JH, Newton P, Newton HJ. Moffatt JH, et al. Cell Microbiol. 2015 May;17(5):621-31. doi: 10.1111/cmi.12432. Epub 2015 Mar 30. Cell Microbiol. 2015. PMID: 25728389 Review.
191 results