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Page 1
Oncogenic Mutants of MEK1: A Trilogy Unfolds.
Maust JD, Whitehead CE, Sebolt-Leopold JS. Maust JD, et al. Among authors: sebolt leopold js. Cancer Discov. 2018 May;8(5):534-536. doi: 10.1158/2159-8290.CD-18-0192. Cancer Discov. 2018. PMID: 29716939
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA. Ohren JF, et al. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. doi: 10.1038/nsmb859. Epub 2004 Nov 14. Nat Struct Mol Biol. 2004. PMID: 15543157
4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
Spicer JA, Rewcastle GW, Kaufman MD, Black SL, Plummer MS, Denny WA, Quin J 3rd, Shahripour AB, Barrett SD, Whitehead CE, Milbank JB, Ohren JF, Gowan RC, Omer C, Camp HS, Esmaeil N, Moore K, Sebolt-Leopold JS, Pryzbranowski S, Merriman RL, Ortwine DF, Warmus JS, Flamme CM, Pavlovsky AG, Tecle H. Spicer JA, et al. J Med Chem. 2007 Oct 18;50(21):5090-102. doi: 10.1021/jm0704548. Epub 2007 Sep 19. J Med Chem. 2007. PMID: 17880056
Deciphering the Complexity of MEK Mutations in the Clinic.
Whitehead CE, Sebolt-Leopold JS. Whitehead CE, et al. Among authors: sebolt leopold js. Cancer Res. 2020 Oct 1;80(19):4042-4043. doi: 10.1158/0008-5472.CAN-20-2611. Cancer Res. 2020. PMID: 33008803
Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition.
Abecunas C, Whitehead CE, Ziemke EK, Baumann DG, Frankowski-McGregor CL, Sebolt-Leopold JS, Fallahi-Sichani M. Abecunas C, et al. Among authors: sebolt leopold js. Cancer Res. 2023 Jan 18;83(2):316-331. doi: 10.1158/0008-5472.CAN-22-0883. Cancer Res. 2023. PMID: 36409827 Free PMC article.
Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence.
Sharma M, Barravecchia I, Teis R, Cruz J, Mumby R, Ziemke EK, Espinoza CE, Krishnamoorthy V, Magnuson B, Ljungman M, Koschmann C, Chandra J, Whitehead CE, Sebolt-Leopold JS, Galban S. Sharma M, et al. Among authors: sebolt leopold js. Mol Cancer Ther. 2024 Jan 3;23(1):24-34. doi: 10.1158/1535-7163.MCT-23-0026. Mol Cancer Ther. 2024. PMID: 37723046 Free PMC article.
59 results