Morgentin R - Search Results

1

Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory.

Morgentin R, Dow M, Aimon A, Karageorgis G, Kalliokoski T, Roche D, Marsden S, Nelson A. Morgentin R, et al. Drug Discov Today. 2018 Sep;23(9):1578-1583. doi: 10.1016/j.drudis.2018.05.007. Epub 2018 May 9. Drug Discov Today. 2018. PMID: 29753124 Free article. Review.

2

Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries.

Craven P, Aimon A, Dow M, Fleury-Bregeot N, Guilleux R, Morgentin R, Roche D, Kalliokoski T, Foster R, Marsden SP, Nelson A. Craven P, et al. Among authors: morgentin r. Bioorg Med Chem. 2015 Jun 1;23(11):2629-35. doi: 10.1016/j.bmc.2014.12.048. Epub 2014 Dec 29. Bioorg Med Chem. 2015. PMID: 25600406

3

Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective.

Karawajczyk A, Giordanetto F, Benningshof J, Hamza D, Kalliokoski T, Pouwer K, Morgentin R, Nelson A, Müller G, Piechot A, Tzalis D. Karawajczyk A, et al. Among authors: morgentin r. Drug Discov Today. 2015 Nov;20(11):1310-6. doi: 10.1016/j.drudis.2015.09.009. Epub 2015 Sep 30. Drug Discov Today. 2015. PMID: 26429298 Free article.

4

Realisation of small molecule libraries based on frameworks distantly related to natural products.

Aimon A, Karageorgis G, Masters J, Dow M, Craven PGE, Ohsten M, Willaume A, Morgentin R, Ruiz-Llamas N, Lemoine H, Kalliokoski T, Eatherton AJ, Foley DJ, Marsden SP, Nelson A. Aimon A, et al. Among authors: morgentin r. Org Biomol Chem. 2018 May 2;16(17):3160-3167. doi: 10.1039/c8ob00688a. Org Biomol Chem. 2018. PMID: 29645063 Free article.

5

Synthesis of sp(3)-rich scaffolds for molecular libraries through complexity-generating cascade reactions.

Flagstad T, Min G, Bonnet K, Morgentin R, Roche D, Clausen MH, Nielsen TE. Flagstad T, et al. Among authors: morgentin r. Org Biomol Chem. 2016 Jun 7;14(21):4943-6. doi: 10.1039/c6ob00961a. Epub 2016 May 12. Org Biomol Chem. 2016. PMID: 27171614

6

Synthesis of 1,4,5 trisubstituted γ-lactams via a 3-component cascade reaction.

Petersen MÅ, Mortensen MA, Cohrt AE, Petersen R, Wu P, Fleury-Brégeot N, Morgentin R, Lardy C, Nielsen TE, Clausen MH. Petersen MÅ, et al. Among authors: morgentin r. Bioorg Med Chem. 2015 Jun 1;23(11):2695-8. doi: 10.1016/j.bmc.2015.01.041. Epub 2015 Jan 31. Bioorg Med Chem. 2015. PMID: 25684425

7

Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.

Fournier JF, Bhurruth-Alcor Y, Musicki B, Aubert J, Aurelly M, Bouix-Peter C, Bouquet K, Chantalat L, Delorme M, Drean B, Duvert G, Fleury-Bregeot N, Gauthier B, Grisendi K, Harris CS, Hennequin LF, Isabet T, Joly F, Lafitte G, Millois C, Morgentin R, Pascau J, Piwnica D, Rival Y, Soulet C, Thoreau É, Tomas L. Fournier JF, et al. Among authors: morgentin r. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2985-2992. doi: 10.1016/j.bmcl.2018.06.029. Epub 2018 Jun 18. Bioorg Med Chem Lett. 2018. PMID: 30122227

8

Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3Kβ and PI3Kδ for the treatment of PTEN-deficient cancers.

Barlaam B, Cosulich S, Degorce S, Fitzek M, Green S, Hancox U, Lambert-van der Brempt C, Lohmann JJ, Maudet M, Morgentin R, Pasquet MJ, Péru A, Plé P, Saleh T, Vautier M, Walker M, Ward L, Warin N. Barlaam B, et al. Among authors: morgentin r. J Med Chem. 2015 Jan 22;58(2):943-62. doi: 10.1021/jm501629p. Epub 2015 Jan 7. J Med Chem. 2015. PMID: 25514658

9

Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.

Plé PA, Jung F, Ashton S, Hennequin L, Laine R, Morgentin R, Pasquet G, Taylor S. Plé PA, et al. Among authors: morgentin r. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6. doi: 10.1016/j.bmcl.2011.11.019. Epub 2011 Nov 12. Bioorg Med Chem Lett. 2012. PMID: 22153662

10

A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production.

Wu P, Petersen MÅ, Cohrt AE, Petersen R, Morgentin R, Lemoine H, Roche C, Willaume A, Clausen MH, Nielsen TE. Wu P, et al. Among authors: morgentin r. Org Biomol Chem. 2016 Aug 7;14(29):6947-50. doi: 10.1039/c6ob01148a. Epub 2016 Jun 30. Org Biomol Chem. 2016. PMID: 27356738

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